Circadian rhythms and the pharmacology of affective illness

Pharmacology & Therapeutics
W C Duncan

Abstract

The chronic effects of antidepressant drugs (ADs) on circadian rhythms of behavior, physiology and endocrinology are reviewed. The timekeeping properties of several classes of ADs, including tricyclic antidepressants, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, serotonin agonists and antagonists, benzodiazepines, and melatonin are reviewed. Pharmacological effects on the circadian amplitude and phase, as well as effects on day-night measurements of motor activity, sleep-wake, body temperature (Tb), 3-methoxy-4-hydroxyphenylglycol, cortisol, thyroid hormone, prolactin, growth hormone and melatonin are examined. ADs often lower nocturnal Tb and affect the homeostatic regulation of sleep. ADs often advance the timing and decrease the amount of slow wave sleep, reduce rapid eye movement sleep and increase or decrease arousal. Together, AD effects on nocturnal Tb and sleep may be related to their therapeutic properties. ADs sometimes delay nocturnal cortisol timing and increase nocturnal melatonin, thyroid hormone and prolactin levels; these effects often vary with diagnosis, and clinical state. The effects of ADs on the coupling of the central circadian pacemaker to photic and nonphotic zeitgebers are dis...Continue Reading

References

Mar 26, 1976·Science·N SitaramJ C Gillin
Feb 1, 1976·British Journal of Clinical Pharmacology·K AdamM Spence
Jan 31, 1979·Psychopharmacology·D J KupferC K Conners
Apr 15, 1977·Science·L P MorinI Zucker
Apr 1, 1978·Acta Psychiatrica Scandinavica·A Weeke, J Weeke
Jan 1, 1976·Annual Review of Medicine·E J Sachar
May 29, 1976·British Medical Journal·G Nikitopoulou, J L Crammer
Oct 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·R Morgan, A J Cheadle
Oct 1, 1976·Acta Psychiatrica Scandinavica·B PflugA Johnsson
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S DaanE R Smith
Jan 1, 1992·Journal of Biological Rhythms·M R Ralph, N Mrosovsky
Jan 1, 1992·Pharmacology & Therapeutics·H Klemfuss
Feb 1, 1992·The International Journal of Neuroscience·R Sandyk, L C Dann
Apr 7, 1992·European Journal of Pharmacology·K TominagaS Watanabe
Oct 1, 1992·Chronobiology International·A J LewyR L Sack
Nov 1, 1992·Journal of Affective Disorders·K DaimonS Takahashi
Nov 1, 1992·International Clinical Psychopharmacology·A Wirz-JusticeR Nil
Jan 1, 1992·Clinical Neuropharmacology·P J Shiromani
Jan 1, 1992·Clinical Neuropharmacology·F DuvalJ P Macher
Jan 1, 1992·Psychopathology·H Kuhs, D Reschke
May 15, 1992·Biological Psychiatry·A L SharpleyP J Cowen
Aug 7, 1992·Brain Research·A R LumiaB Possidente
Jul 1, 1992·Journal of Affective Disorders·V DelvenneJ Mendlewicz
Feb 1, 1992·Journal of Affective Disorders·D G Beersma, R H van den Hoofdakker
Mar 1, 1992·Journal of Affective Disorders·P FeuilladeG Darcourt
Jan 1, 1992·Psychopharmacology·A L van BemmelR van Diest
Mar 1, 1992·The Japanese Journal of Psychiatry and Neurology·H NagayamaT Yanagisawa
Apr 15, 1992·Biological Psychiatry·G HöflichR Schmidt
May 11, 1991·Lancet·M DahlitzJ D Parkes
Aug 1, 1990·Electroencephalography and Clinical Neurophysiology·D G BeersmaI Everhardus
Jan 1, 1991·Journal of Biological Rhythms·R L SackL D Keith
Nov 25, 1991·Neuroscience Letters·D S MinorsA Wirz-Justice
Jan 1, 1991·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J Mendlewicz

❮ Previous
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Citations

Sep 30, 1999·Life Sciences·D K Raap, L D Van de Kar
Aug 21, 2001·Journal of Affective Disorders·A Preti, P Miotto
Feb 28, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L van LondenD De Wied
Jun 26, 2010·Nature Reviews. Drug Discovery·Christian de BodinatMark J Millan
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·M M C Gonzalez, G Aston-Jones
Feb 2, 2010·Biological & Pharmaceutical Bulletin·Shigehiro Ohdo
Jan 4, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shigehiro Ohdo
Dec 25, 2013·BioMed Research International·Swati C JagdaleAniruddha R Chabukswar
Dec 12, 2012·ISRN Cardiology·Karina W Davidson
May 7, 2014·Drug Development and Industrial Pharmacy·Yingna XueWeisan Pan
Jun 10, 2011·Journal of Pharmaceutical Sciences·Shigehiro OhdoAhmed Hamdan
Oct 29, 2011·Sleep Medicine Reviews·Sun Young Rosalia YoonColin Shapiro
Oct 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shan-Yang Lin, Yoshiaki Kawashima
Jul 17, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Robert L GannonMark J Millan
Oct 1, 2008·Sleep Medicine·Sarah Laxhmi ChellappaChristian Cajochen
Jan 24, 2007·Journal of Affective Disorders·Greg Murray
Sep 29, 2015·Stress : the International Journal on the Biology of Stress·Reka NatarajanBryan K Yamamoto
Feb 15, 2008·Bipolar Disorders·Paola SalvatoreRoss J Baldessarini
Oct 27, 2010·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Gregor Hasler
Aug 18, 2010·Bipolar Disorders·Greg Murray, Allison Harvey
Jan 13, 2006·Biological Psychiatry·Gregor HaslerHusseini K Manji
Mar 15, 2013·Expert Opinion on Investigational Drugs·Trevor R Norman
Mar 5, 2004·Expert Opinion on Therapeutic Targets·Jeffrey Sprouse
Jun 1, 1999·Journal of Receptor and Signal Transduction Research·U L MullinsA S Eison
Mar 3, 2007·Drug Metabolism and Pharmacokinetics·Shigehiro Ohdo
Aug 21, 2002·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hideaki SuzukiShunkichi Endo
Feb 2, 2015·The International Journal of Neuropsychopharmacology·Stefano ComaiGabriella Gobbi
Apr 4, 2015·Journal of Pharmacological Sciences·Kazumi MiyawakiHiroyuki Yoshimura

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