Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio

Clinica Chimica Acta; International Journal of Clinical Chemistry
S NomuraK Ueda

Abstract

We evaluated the circadian rhythms in the plasma concentrations of cortisol, cortisone and their free forms, and in the cortisone/cortisol ratios by means of reversed-phase high performance liquid chromatography in normal adult subjects. Plasma concentrations of cortisone, as well as cortisol, exhibited a circadian rhythm. The ratios of cortisone/cortisol remained almost constant during the waking hours of normal subjects. Changes in the cortisone/cortisol ratios previously reported in patients with various diseases exceeded the diurnal changes detected in the present study. Thus, the determination of the cortisone/cortisol ratio provides information that is useful in assessing the adrenal function of patients with various diseases.

References

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Dec 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T G Brien
Dec 9, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·S NomuraK Ueda

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Citations

Jun 15, 2007·Intensive Care Medicine·Bala VenkateshJohn Prins
Jan 5, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Claudia A Staab, Edmund Maser
Apr 25, 2015·American Journal of Hypertension·Carolina ValdiviaCarlos E Fardella
Sep 29, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Yanyan HanEdmund Maser
Jul 18, 2014·Drug Metabolism and Pharmacokinetics·Shuoye YangXijing Chen
Oct 19, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alina PlenisJarosław Skokowski
Aug 1, 2013·Physiological Reviews·Karen ChapmanJonathan Seckl
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·B WeberI Heuser
Jul 30, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Markus PuchingerPeter H Rehak
Apr 28, 2021·Journal of Diabetes and Its Complications·Pinar Gumus BalikciogluStuart Chalew
Jan 28, 2006·Journal of Psychosomatic Research·Walid K JerjesAnthony J Cleare

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