Circadian rhythms of body temperature and locomotor activity in aging BALB/c mice: early and late life span predictors

Biogerontology
Andrea BassoMarco Malavolta

Abstract

Impairment of one or more parameters of circadian rhythms (CR) of body temperature (BT) and locomotor activity (LMA) are considered among the hallmarks of mammalian aging. These alterations are frequently used as markers for imminent death in laboratory mice. However, there are still contradictory data for particular strains and it is also uncertain which changes might predict senescence changes later in life, including the force of mortality. In the present paper we use telemetry to study LMA and CR of BT during aging of BALB/c mice. At our knowledge this is the first time that CR of BT and LMA are investigated in this strain in a range of age covering the whole lifespan, from young adult up to very old age. CR of BT was analyzed with a cosine model using a cross sectional approach and follow-up measurements. The results show that BT, LMA, amplitude, goodness-of-fit (GoF) to circadian cycle of temperature decrease with different shapes during chronological age. Moreover, we found that the % change of amplitude and BT in early life (5-19 months) can predict the remaining lifespan of the mice. Later in life (22-32 months), best predictors are single measurements of LMA and GoF. The results of this study also offer potential meas...Continue Reading

References

May 1, 1975·Journal of Gerontology·C L Goodrick
Dec 26, 1992·Annals of the New York Academy of Sciences·L PiantanelliA Basso
Jan 1, 1991·Journal of the American Geriatrics Society·M A Brock
Jan 1, 1991·Experimental Gerontology·T H Monk
Jan 1, 1990·Experimental Gerontology·R RefinettiE Satinoff
Mar 1, 1986·Neurobiology of Aging·M V VitielloP N Prinz
Jan 1, 1985·Journal of Gerontology·M I TalanJ R Whitaker
May 13, 1985·Mechanisms of Ageing and Development·M A ReynoldsM Talan
Nov 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·C J Estler
Jul 1, 1966·Journal of Gerontology·J B Storer
Jan 1, 1983·Experimental Gerontology·T Balmagiya, S J Rozovski
Jan 1, 1984·Experimental Gerontology·M Talan
Jan 1, 1982·Neurobiology of Aging·E D WeitzmanJ C Zimmerman
May 1, 1981·Mechanisms of Ageing and Development·G S Habicht
Oct 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·R B McDonaldB A Horwitz
Sep 1, 1995·Experimental Gerontology·T H MonkP R Houck
Jul 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R L Walford, S R Spindler
Sep 25, 1999·Physiology & Behavior·W S HunterC J Meliska
May 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R A Miller, N L Nadon
Apr 9, 2001·Mechanisms of Ageing and Development·V N AnisimovL Piantanelli
Apr 27, 2002·Pflügers Archiv : European journal of physiology·C BenstaaliY Touitou
Nov 6, 2003·Journal of Applied Physiology·W Larry Kenney, Thayne A Munce
Oct 31, 2006·Physiology & Behavior·Dietmar Weinert, Jim Waterhouse
Jan 2, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David W Degroot, W Larry Kenney
Apr 24, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Matthew T Andrews
Aug 10, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brad A Rikke, Thomas E Johnson
Nov 4, 2008·Nature Cell Biology·George A GarinisJan H J Hoeijmakers
Oct 23, 2009·Diabetes·Manuel Sanchez-AlavezTamas Bartfai
Jul 17, 2010·Age·Manuel Sanchez-AlavezBruno Conti
Nov 17, 2011·Gerontology·Clark M Blatteis
Aug 7, 2012·Disease Models & Mechanisms·Elysse M KnightCatherine B Lawrence
Nov 16, 2012·Nature·Joseph Bass
Dec 5, 2012·The Journal of Nutrition, Health & Aging·L VolicerE G Stopa
Jan 15, 2013·Physiology & Behavior·Brianna N GaskillJoseph P Garner
Feb 26, 2013·Critical Reviews in Oncology/hematology·Vladimir N Anisimov, Andrzej Bartke
Dec 18, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Haiming LiuLaDora V Thompson
Apr 3, 2015·Biogerontology·Gerald KeilJoão Pedro de Magalhães

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Citations

Jun 7, 2019·Experimental Animals·Akitoshi ChikamotoMasayoshi Kuwahara
Apr 21, 2019·Physiological Reports·Candace N RecenoLara R DeRuisseau
Oct 31, 2020·GeroScience·Kristopher J GrohnKelsey J Moody

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