PMID: 3768669Sep 10, 1986Paper

Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro

Brain Research
D J Earnest, C D Sladek

Abstract

A culture system was developed to study intrinsic oscillations within rat suprachiasmatic nuclei for long periods of time. After isolation in static organ cultures, individual rat suprachiasmatic explants released vasopressin in a circadian fashion for at least 4 cycles. This finding suggests that the suprachiasmatic nucleus contains one or more self-sustained circadian oscillators, and that this method of measuring circadian rhythms from individual suprachiasmatic organ cultures may prove to be a valuable model for elucidating the physiology and biochemistry of mammalian circadian pacemakers.

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Citations

Dec 31, 1997·The Journal of Comparative Neurology·M M Moga, R Y Moore
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Aug 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nathan G HatcherJonathan V Sweedler

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