Jan 29, 2011

Circadian rhythms persist without transcription in a eukaryote

Nature
John S O'NeillAndrew J Millar

Abstract

Circadian rhythms are ubiquitous in eukaryotes, and coordinate numerous aspects of behaviour, physiology and metabolism, from sleep/wake cycles in mammals to growth and photosynthesis in plants. This daily timekeeping is thought to be driven by transcriptional-translational feedback loops, whereby rhythmic expression of 'clock' gene products regulates the expression of associated genes in approximately 24-hour cycles. The specific transcriptional components differ between phylogenetic kingdoms. The unicellular pico-eukaryotic alga Ostreococcus tauri possesses a naturally minimized clock, which includes many features that are shared with plants, such as a central negative feedback loop that involves the morning-expressed CCA1 and evening-expressed TOC1 genes. Given that recent observations in animals and plants have revealed prominent post-translational contributions to timekeeping, a reappraisal of the transcriptional contribution to oscillator function is overdue. Here we show that non-transcriptional mechanisms are sufficient to sustain circadian timekeeping in the eukaryotic lineage, although they normally function in conjunction with transcriptional components. We identify oxidation of peroxiredoxin proteins as a transcript...Continue Reading

  • References28
  • Citations170

References

  • References28
  • Citations170

Mentioned in this Paper

Metabolic Process, Cellular
Transcription, Genetic
Protein Synthesis Inhibitors
Alkyl Hydroperoxide Reductase D
Sustain
Oxidation
TRNT1 gene
Chlorophyta
Metabolic Pathway
Circadian Rhythm Pathway 2

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