PMID: 6989263Mar 1, 1980Paper

Circadian sleep and feeding patterns in the rat: possible dependence on lipogenesis and lipolysis

The American Journal of Physiology
J Danguir, S Nicolaidis


Sleep and feeding patterns were continuously recorded in rats under intravenous saline (control) and alternating insulin-epinephrine (experimental) infusions. The infusion of insulin (lipogenetic hormone) during the normally light period (0800-1600) replaced by epinephrine (lipolytic hormone) during the normally lipogenetic dark period (1600-0800) resulted in a complete inversion of the normal circadian distribution of sleep and feeding patterns and also of their correlation. Insulin infusion resulted in low blood glucose and glycerol levels whereas epinephrine increased these physiological parameters. Different control conditions showed that the fluctuations of sleep and feeding were dependent on the rate of utilization of the circulating metabolites at the cellular level. These results together with previous data suggest that the relation between sleep and feeding and their concomitant circadian fluctuation are possibly modulated by a common factor, namely the metabolic rate that is influenced by the lipogenesis/lipolysis rate.


Apr 1, 1979·Physiology & Behavior·J Danguir, S Nicolaidis
Apr 1, 1978·European Journal of Clinical Investigation·T Akerstedt, L Levi
Nov 1, 1978·Physiology & Behavior·J Danguir, S Nicolaidis
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Dec 31, 2002·Physiological Reviews·L Arthur Campfield, Françoise J Smith
Feb 15, 2013·Toxicology and Industrial Health·Jaroslava NovákováFrantisek Nistiar

Related Concepts

Blood Glucose
Circadian Rhythms
Feeding Patterns
Sleep, Slow-Wave

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