Circadian stage-dependent effects of epidermal growth factor on deoxyribonucleic acid synthesis in ten different organs of the adult male mouse

Endocrinology
Y C YehL E Scheving

Abstract

Epidermal growth factor (EGF) previously isolated from the submandibular gland of mice was injected ip at different circadian stages into separate subgroups of adult male CD2F1 mice. Subsequent to each of the five time points of injection (0900, 1500, 1800, 2100, and 0300 h for animals standardized to 12 h of light alternating with 12 h of darkness: light, 0600-1800 h; dark, 1800-0600 h), five animals were killed at 4, 8, and 12 h after the EGF injection; comparable control groups were injected only with the carrier substance. Thirty minutes before sacrifice, each mouse was injected ip with 24 muCi [3H]thymidine. Incorporation of [3H]thymidine into the DNA of the aorta, lung, liver, cornea, testes, kidney, parotid, thymus, spleen, and bone marrow as well as the mitotic index of the corneal epithelium was determined. The results indicate that EGF may play a role in the positive control of growth of many of these tissues, especially the aorta, lung, liver, and cornea. EGF may also play a role in inhibiting growth of the thymus, spleen, and bone marrow. Moreover, the stimulatory effect of EGF on the growth of the various tissues appears to be especially enhanced in mice injected at 1500 h and killed 4 h later at 1900 h.

Citations

Nov 1, 1991·Journal of Surgical Oncology·G ScambiaL C Spagnolo
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·M YamaharaE Tahara
May 15, 1987·Archives of Biochemistry and Biophysics·M Soley, M D Hollenberg
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y KatoY Sugiyama
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KajikawaE Tahara
May 1, 1992·Scandinavian Journal of Gastroenterology·T N RasmussenP S Olsen
Jan 1, 1991·Annals of the New York Academy of Sciences·L E SchevingR J Feuers
Jan 30, 1990·Biochemical and Biophysical Research Communications·S Johansson, G Andersson
Aug 1, 1989·The Anatomical Record·L A SchevingL E Scheving
Nov 20, 1982·The Journal of Experimental Zoology·J J Berger, C W Daniel
Nov 28, 2002·Gastroenterology·Robert S CarverWilliam E Russell
Dec 1, 1983·The American Journal of Anatomy·L E SchevingL A Scheving
May 1, 1992·Experimental Cell Research·J G de DiegoJ L Carpentier
Oct 1, 1990·Differentiation; Research in Biological Diversity·R TawaS Hirose
May 2, 2014·Annals of Medicine·Matúš SotákJiří Pácha
Sep 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S JohanssonG Andersson
Jan 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U MartiA L Jones
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J St Hilaire, A L Jones
Jun 14, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lawrence A SchevingWilliam E Russell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.