PMID: 6168003Jan 1, 1981Paper

Circadian variation in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine and p-chloroamphetamine in the mouse

Psychopharmacology
C Singleton, C A Marsden

Abstract

Circadian fluctuations were measured in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA) in male BK. TO mice. The effects of depleting brain 5-hydroxytryptamine (5-HT) with p-chlorophenylalanine (PCPA) on the 5-MeODMT in the mouse were also studied. Changes in brain 5-HT and 5-hydroxyindoleacetic (5-HIAA) were concomitantly determined. PCPA (400 mg/kg IP twice on consecutive days) significantly increased the number of head twitches induced by 5-MeODMT (5 mg/kg IV) on days 3 and 5 after the initial injection of PCPA when 5-HT and 5-HIAA were also significantly reduced. On day 12, there was no significant difference in the number of head twitches between mice administered PCPA and those given saline, and 5-HT and 5-HIAA levels were nearly back to normal. PCPA, using the same dose schedule, significantly reduced the number of head twitches induced by PCA when PCA was administered 24 h after the second injection of PCPA (day 3. Mice maintained on a 12-h light-dark cycle showed a maximum response to the direct 5-HT receptor agonist 5-MeODMT (5 mg/kg IV) towards the end of the dark period, when the 5-HT level was at its lowest. p-Chloroamphetamine, which causes release o...Continue Reading

References

Aug 1, 1978·British Journal of Pharmacology·G CurzonC A Marsden
May 25, 1979·Psychopharmacology·W N Tapp, F A Holloway
Mar 1, 1976·European Journal of Pharmacology·M E Trulson, B L Jacobs
Nov 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·P SteigradA A Borbély
Jun 1, 1977·Pharmacology, Biochemistry, and Behavior·R L BornscheinR P Smith
Feb 15, 1979·European Journal of Pharmacology·M E Trulson, B L Jacobs
Nov 24, 1977·Psychopharmacology·H NagayamaR Takahashi
May 1, 1979·Pharmacology, Biochemistry, and Behavior·C A Marsden, B King
Feb 1, 1963·British Journal of Pharmacology and Chemotherapy·S J CORNEB T WARNER

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Citations

Jul 31, 2012·Psychopharmacology·José L MorenoJavier González-Maeso
Jan 1, 1987·Progress in Neurobiology·A Wirz-Justice
Oct 8, 1999·Psychosomatic Medicine·H Nagayama
Apr 11, 2012·Pharmacology, Biochemistry, and Behavior·Adam L HalberstadtMark A Geyer
Jul 19, 2014·Behavioural Brain Research·Adam L Halberstadt
May 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dhwanil A DalwadiJohn A Schetz
Jul 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·R McCauleyR McCulloch
Mar 17, 2018·Frontiers in Pharmacology·Emmanuelle A D SchindlerDeepak C D'Souza

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