Circadian Variation of Ventricular Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia

JACC. Clinical Electrophysiology
Christina Y MiyakeDominic Abrams

Abstract

The aim of this paper was to investigate whether ventricular arrhythmias in children with catecholaminergic polymorphic ventricular tachycardia (CPVT) show circadian patterns. Circadian arrhythmic patterns have been established in long QT, Brugada, and early repolarization, but have not been investigated in CPVT. This is a multicenter, retrospective review of pediatric CPVT patients, age <21 years at diagnosis. Timing of ventricular tachycardia (VT ≥3 beats) was assessed during 24-h continuous monitoring (Holter, implantable loop recorder, implantable cardioverter defibrillator) and by eliminating sleep hours, in addition to sporadic exercise stress tests. Morning was defined as 6:00 am to 11:59 am, afternoon 12:00 pm to 5:59 pm, and evening 6:00 pm to 11:59 pm. Distribution of VT events was compared by time of day, day of week, age, and sex. Eighty patients (53% male), 61% with an ICD, experienced 423 VT events during a median follow-up time of 6 years (interquartile range: 2 to 10 years). When compared to morning hours, VT was more likely to occur in the afternoon (odds ratio [OR]: 2.54; 95% confidence interval [CI]: 1.69 to 3.83) or evening hours (OR: 2.91; 95% CI: 1.82 to 4.67). The predominance of afternoon/evening events ...Continue Reading

References

Jul 1, 1992·The American Journal of Cardiology·S N WillichJ E Muller
Mar 1, 1986·British Heart Journal·R S BextonA J Camm
Oct 1, 1987·The American Journal of Cardiology·S N WillichJ E Muller
Jan 1, 1987·Circulation·J E MullerP H Stone
Sep 15, 1995·Circulation·T Q KongA H Kadish
May 1, 1993·Circulation·S N WillichJ E Muller
Apr 2, 2003·Circulation·Takeshi YamashitaHiroshi Watanabe
Sep 25, 2008·Pacing and Clinical Electrophysiology : PACE·Thomas J KiernanBernard J Gersh
Nov 21, 2009·Circulation Research·Tami A Martino, Michael J Sole
Mar 6, 2010·Circulation Research·David J Durgan, Martin E Young
Feb 15, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Raymond W SyAndrew D Krahn
Mar 1, 2012·Nature·Darwin JeyarajMukesh K Jain
Jul 13, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Masateru TakigawaWataru Shimizu
Oct 25, 2014·The International Journal of Behavioral Nutrition and Physical Activity·Anna GoodmanUNKNOWN International Children’s Accelerometry Database (ICAD) Collaborators

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