PMID: 6400660Jan 1, 1984Paper

Circannual rhythm of insulin release and hypoglycemic effect of tolbutamide stimulus in healthy man

Chronobiology International
A Del PonteS Sensi

Abstract

Four healthy non obese young volunteers were observed for a 24-hr period, every other month, over the course of one year. Tolbutamide was injected i.v. each day of the experiment every four hours. Tolbutamide-induced insulin secretion (T.I.I.S.) was evaluated by planimetrically measuring insulin areas above basal levels. Tolbutamide-induced hypoglycemic effect was evaluated by measuring the blood glucose difference between the 5th and 25th minute after the drug injection (delta G5'-25'). The macroscopic evaluation of T.I.I.S. and delta G5'-25' (mean chronograms) permitted the detection of the existence of a circannual variation of both variables. In particular the maximum level of the blood glucose drop (delta G5'-25') was registered in February. Subsequently the quantification of the rhythm of T.I.I.S. was obtained by fitting a sine curve, according to the Cosinor method. The highest insulin release was confirmed in winter. As previously documented, the existence of a statistically significant circadian rhythm of T.I.I.S. was confirmed in the morning, i.e. the same period of the day in which insulin-induced hypoglycemia occurs.

References

Aug 1, 1976·The Journal of Clinical Endocrinology and Metabolism·S Sensi, F Capani
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·E HausT Omae

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Citations

Jun 13, 2002·Clinical and Experimental Pharmacology & Physiology·Keiko UezonoPietro Cugini
Aug 14, 2002·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Brian C FochtW Jack Rejeski

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