circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA

Cell Death & Disease
Jia-Xiang ZhangRui-Lan Wang

Abstract

Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important players involved in many biological processes. circHIPK3 has been identified as the one of the most abundant circRNAs in human lung. In this study, we characterized the role of circHIPK3 in pulmonary fibrosis. We revealed that circHIPK3 is upregulated in bleomycin-induced pulmonary fibrosis mice model, FMT-derived myofibroblasts. circHIPK3 silencing can ameliorate FMT and suppress fibroblast proliferation in vivo and vitro. Fundamentally, circHIPK3 regulates FMT by functioning as an endogenous miR-338-3p sponge and inhibit miR-338-3p activity, thereby leading to increased SOX4 and COL1A1 expression. Moreover, dysregulated circHIPK3 expression was detected in the clinical samples of patients with idiopathic pulmonary fibrosis. Intervention of circHIPK3 may represent a promising therapy for pulmonary fibrosis.

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Citations

May 19, 2020·Journal of Clinical Laboratory Analysis·Yezhao WangJunming Guo
Jun 6, 2020·Frontiers in Oncology·Jingyuan WenLiang Chu
Aug 11, 2020·BioMed Research International·Zhongyue HuangJiangni Xia
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiwei YangBurton B Yang
Nov 25, 2020·Molecular Therapy. Nucleic Acids·Ramanathan SaikishoreSubpiramaniyam Sivakumar
Feb 22, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiaoniu DaiJie Chao
Mar 12, 2021·Frontiers in Medicine·Jiang ZhouZhangui Tang
May 13, 2021·Cancer Cell International·Yihan Fu, Hong Sun
Jun 13, 2021·Ageing Research Reviews·Yang YangYe Tian
Jun 11, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jia-Xiang ZhangRui-Lan Wang
Oct 10, 2020·Seminars in Cancer Biology·Feiya LiBurton B Yang

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Methods Mentioned

BETA
PCRs
electrophoresis
transfection
transfections
Immunoprecipitation
RIP

Software Mentioned

Image
circbase
Pro Plus

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