PMID: 2504444Jan 1, 1989Paper

Circling behavior produced by the unilateral intra-accumbens injection of dopaminergic agonist and two dopaminergic antagonists in mice

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
O MrabetC Destrade

Abstract

Unilateral intra-accumbens injection of apomorphine, a dopaminergic agonist, produced circling contralateral to the site of injection in Balb/c mice. Unilateral intra-accumbens injection of haloperidol and metoclopramide, two dopaminergic antagonists, produced ipsilateral circling. These results support the hypothesis that the dopaminergic receptors in the nucleus accumbens also contribute to the direction of locomotor activity.

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