CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Min JiangHongling Yang

Abstract

Circular RNAs (circRNAs) are transcribed prevalently in the genome; however, their potential roles in multiple cardiovascular diseases, particularly preeclampsia (PE), are not yet well understood. This study investigated the expression profiles of circRNAs and explored circRNA-mediated pregnancy-associated plasma protein A (PAPP-A) expression as a potential biomarker for PE before 20 weeks of pregnancy. A nested case-control two-phase screening/validation study was performed in pregnant women before 20 weeks of gestation (before clinical diagnosis) at Guangzhou Women and Children's Medical Center from 2012 to 2015. In the screening phase, circRNA expression profiles of blood cells were assessed using a human circRNA microarray, which was designed to detect simultaneously 5396 circRNAs, in 5 patients with PE and 5 age- and gestational week-matched controls. In the validation phase, 18 circRNAs in blood cells predicted by bioinformatics tools were validated by quantitative reverse transcription PCR in a cohort of 60 patients (PE and age-, gestational week-, and sample storage time-matched controls). Then, we examined the involvement of circRNAs in PE-related pathways via interactions with miRNAs by multiple bioinformatics approac...Continue Reading

Citations

Sep 3, 2019·Molecular Reproduction and Development·Rana ShafabakhshZatollah Asemi
Sep 23, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Guillermo Jacobo-BacaLaura Elia Martínez-de-Villarreal
Jul 10, 2020·Curēus·Andong HeRuiman Li
Jun 14, 2019·Disease Markers·Ningyi Jia, Jian Li
Jun 27, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mohamed Zaiou
Jan 5, 2021·Frontiers in Bioengineering and Biotechnology·Yuxin RanHongbo Qi
May 18, 2021·Frontiers in Physiology·Ailing ChenYing Chen

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