circRNA_0084043 promote malignant melanoma progression via miR-153-3p/Snail axis.

Biochemical and Biophysical Research Communications
Wenkang LuanJinlong Wang

Abstract

Circular RNAs (circRNAs) has been found to play an important role in the regulation of multiple diseases, and participate in cancer development. However, the role of circRNA in malignant melanoma has not been reported. In this study, human circRNA microarray was used to screen the dysregulated circRNA in melanoma. We found that circRNA_0084043 was significantly up-regulated in melanoma tissue, and the result was replicated in a larger sample size. High circRNA_0084043 expression was an independent risk factor of overall survival in melanoma patients. circRNA_0084043 promotes melanoma cell proliferation, invasion and migration. Bioinformatics and luciferase reporter assays confirmed that circRNA_0084043 directly binds to miR-153-3p, and Snail is directly targeted by miR-153-3p. We also demonstrated that circRNA_0084043 may act as the sponge of miR-153-3p to up-regulate Snail expression, and consequently function as an oncogene in melanoma. Overall, this result elucidates a new mechanism for circRNA_0084043 in melanoma development and provides a potential therapeutic target for melanoma patients.

Citations

Apr 28, 2019·Journal of Biomedical Science·Chun-Ying Yu, Hung-Chih Kuo
Sep 4, 2019·Cancer Gene Therapy·Abbas AbiSeyed Mohammad Gheibi Hayat
May 29, 2020·Biomarkers in Medicine·Jamal HallajzadehZatollah Asemi
Sep 6, 2020·Journal of Molecular Neuroscience : MN·Hui QuanWeifeng Wang
Sep 19, 2019·Molecular Cancer·Bing-Qing ShangJin Bai
Dec 12, 2018·Journal of Cellular Physiology·Jing WangWeifeng Lu
Jun 21, 2020·Signal Transduction and Targeted Therapy·Lei LiuShouping Xu
May 10, 2020·Bioscience, Biotechnology, and Biochemistry·Yong HeXiong-Zhang Yin
Aug 18, 2020·Journal of Experimental & Clinical Cancer Research : CR·Zhen LiXiaoming Gu
Dec 8, 2019·Cell Biochemistry and Biophysics·Cheng JinMeishan Piao
Mar 17, 2021·Biochemical and Biophysical Research Communications·Baoyu HeYujun Hao
Apr 22, 2021·Journal of Oncology·Shuying ChenYong Lin
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Keyun TangHongzhong Jin
Jun 3, 2021·Cancers·Victor Mayoral-VaroWolfgang Link
Jun 4, 2021·Molecular Oncology·Barbara MonticoElisabetta Fratta
Jun 26, 2021·The World Journal of Men's Health·Jiancheng PanQiliang Cai
Jun 29, 2021·Genes & Diseases·Yong HuangHongtao Ren
Jul 20, 2021·Frontiers in Cell and Developmental Biology·Wei LiuWu Wen
Jul 30, 2021·Archives of Gynecology and Obstetrics·Li ZhangXiaojun Cai
Aug 1, 2021·Oncogene·Nicol MecozziFlorian A Karreth
Aug 21, 2021·Essays in Biochemistry·Giorgio DuranteManuela Ferracin
Aug 13, 2021·Expert Review of Molecular Diagnostics·Khatereh KhorsandiHeidi Abrahamse

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