CircRNAs: role in human diseases and potential use as biomarkers.

Cell Death & Disease
Lorena VerduciGiovanni Blandino

Abstract

Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively low but due to the circular configuration, their stability is very high. In addition, circRNAs display high degree of tissue specificity. The sponging activity of circRNAs toward microRNAs is the best-described mode of action of circRNAs. However, the ability of circRNAs to bind with specific proteins, as well as to encode short proteins, propose alternative functions. This review introduces the biogenesis of circRNAs and summarizes the roles played by circRNAs in human diseases. These include examples of their functional roles in several organ-specific cancers, such as head and neck and breast and lung cancers. In addition, we review potential functions of circRNAs in diabetes, cardiovascular, and neurodegenerative diseases. Recently, a growing number of studies have demonstrated involvement of circRNAs in a wide spectrum of signaling molecular pathways, but at the same time many different and controversial views on circRNAs role and function are emerging. We conclude by offering cellular homeostasis generated by networks comprising circular RNAs, othe...Continue Reading

References

Jun 30, 2005·Journal of Cell Science·Daniel TonderaAnsgar Santel
Nov 17, 2010·Genes & Development·Luca GrumolatoStuart A Aaronson
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Feb 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan LiLihui Lai
Dec 20, 2012·RNA·William R JeckNorman E Sharpless
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Mar 1, 2013·Nature·Sebastian MemczakNikolaus Rajewsky
Sep 17, 2013·Molecular Cell·Yang ZhangLing-Ling Chen
Sep 17, 2013·PLoS Genetics·Julia SalzmanPatrick O Brown
Jan 1, 2014·Wiley Interdisciplinary Reviews. RNA·Rasmus O Bak, Jacob Giehm Mikkelsen
May 9, 2014·Nature Biotechnology·William R Jeck, Norman E Sharpless
Sep 23, 2014·Molecular Cell·Reut Ashwal-FlussSebastian Kadener
Sep 23, 2014·Cell·Xiao-Ou ZhangLi Yang
Oct 5, 2014·Genes & Development·Dongming Liang, Jeremy E Wilusz
Nov 8, 2014·Clinical Chemistry·Jae Hoon BahnXinshu Xiao
Dec 30, 2014·Cell Reports·Stefan StarkeAlbrecht Bindereif
Jan 6, 2015·Cell Reports·Andranik IvanovNikolaus Rajewsky
Feb 11, 2015·Nature Structural & Molecular Biology·Zhaoyong LiGe Shan
Feb 18, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peifei LiJunming Guo
Mar 15, 2015·Cell·Simon J ConnGregory J Goodall
Mar 25, 2015·Cancer Biology & Therapy·Mona SobhaniHong Chang
Apr 30, 2015·Molecular Cell·Agnieszka Rybak-WolfNikolaus Rajewsky
Sep 1, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Chongbiao HuangDaliang Qi
Sep 19, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana Sebio, Heinz-Josef Lenz
Dec 23, 2015·EMBO Reports·Silvia Di AgostinoGiovanni Blandino
Feb 28, 2016·Lancet·Philip ScheltensWiesje Maria Van der Flier
Apr 14, 2016·Cell Reports·Yang ZhangLing-Ling Chen

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Citations

Jul 9, 2021·Frontiers in Cell and Developmental Biology·Yuan ZhiKeqian Zhi
Aug 28, 2021·Genes·Kyle R CochranSupriyo De
Sep 25, 2021·Cellular & Molecular Biology Letters·Zahra ForuzandehMohammad Reza Alivand
Nov 27, 2021·Technology in Cancer Research & Treatment·Chenyue DaiYuanyuan Ma

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