circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis

Cell Death & Disease
Jian-Zhen XuMin Chen

Abstract

More and more evidence indicates that circular RNAs (circRNAs) have important roles in several diseases, especially in cancers. However, their involvement remains to be investigated in breast cancer. Through screening circRNA profile, we identified 235 differentially expressed circRNAs in breast cancer. Subsequently, we explored the clinical significance of two circTADA2As in a large cohort of triple-negative breast cancer (TNBC), and performed functional analysis of circTADA2A-E6 in vitro and in vivo to support clinical findings. Finally, we evaluated the effect of circTADA2A-E6 on miR-203a-3p and its target gene SOCS3. We detected two circRNAs, circTADA2A-E6 and circTADA2A-E5/E6, which were among the top five differentially expressed circRNAs in breast cancer. They were consistently and significantly decreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patient survival for TNBC. Especially, circTADA2A-E6 suppressed in vitro cell proliferation, migration, invasion, and clonogenicity and possessed tumor-suppressor capability. circTADA2A-E6 preferentially acted as a miR-203a-3p sponge to restore the expression of miRNA target gene SOCS3, resulting in a less aggressive oncogenic...Continue Reading

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Citations

Jun 5, 2019·Bioscience Reports·Si-Ying ZhouJin-Hai Tang
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Methods Mentioned

BETA
chip
transfection
xenografts
Feature Extraction
electrophoresis
PCR

Software Mentioned

Prism
Arraystar circRNA
PITA
R
Arraystar circRNA program
CircNet
Arraystar
CircInteractome
SPSS
TargetScan

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