Circuit Mechanisms of Reward, Anhedonia, and Depression

The International Journal of Neuropsychopharmacology
Anna HöflichRupert Lanzenberger

Abstract

Pleasure and motivation are important factors for goal-directed behavior and well-being in both animals and humans. Intact hedonic capacity requires an undisturbed interplay between a number of different brain regions and transmitter systems. Concordantly, dysfunction of networks encoding for reward have been shown in depression and other psychiatric disorders. The development of technological possibilities to investigate connectivity on a functional level in humans and to directly influence networks in animals using optogenetics among other techniques has provided new important insights in this field of research.In this review, we aim to provide an overview on the neurobiological substrates of anhedonia on a network level. For this purpose, definition of anhedonia and the involved reward components are described first, then current data on reward networks in healthy individuals and in depressed patients are summarized, and the roles of different neurotransmitter systems involved in reward processing are specified. Based on this information, the impact of different therapeutic approaches on reward processing is described with a particular focus on deep brain stimulation (DBS) as a possibility for a direct modulation of human br...Continue Reading

References

Sep 1, 1979·The Journal of Comparative Neurology·M Herkenham, W J Nauta
Aug 1, 1976·Journal of Abnormal Psychology·L J ChapmanM L Raulin
Jan 1, 1983·Archives of General Psychiatry·J FawcettR D Gibbons
Jul 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·R P SnaithP Trigwell
Jun 2, 1998·Nature·M J KoeppP M Grasby
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Dec 1, 1999·Biological Psychiatry·A CarlssonM L Carlsson
Jul 24, 2002·The International Journal of Neuropsychopharmacology·Adam OpbroekRachel Manber
Aug 20, 2002·Psychopharmacology·Jeffrey H MeyerSylvain Houle
Oct 11, 2003·Biological Psychiatry·Susan M Learned-CoughlinBengt Långstrom
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David H ZaldAlain Dagher
Oct 11, 2005·Journal of Affective Disorders·Miklós ArgyelánLászló Pávics
Mar 29, 2006·Biological Psychiatry·Eric J Nestler, William A Carlezon
Oct 13, 2006·Psychopharmacology·M Flavia Barbano, Martine Cador
Mar 7, 2007·Archives of General Psychiatry·Boadie W Dunlop, Charles B Nemeroff
Apr 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas E SchlaepferVolker Sturm
May 11, 2007·Schizophrenia Research·David E GardMichael F Green
May 25, 2007·Nature·Masayuki Matsumoto, Okihide Hikosaka
Jun 29, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huifang Ji, Paul D Shepard
Mar 4, 2008·Psychopharmacology·Kent C Berridge, Morten L Kringelbach
Jun 27, 2008·Brain : a Journal of Neurology·P KumarJ D Steele
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Björn H SchottAndreas Bauer
Mar 4, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Siegfried Kasper, Michel Hamon
Apr 30, 2009·Annual Review of Neuroscience·Anatol C Kreitzer
May 5, 2009·The American Journal of Psychiatry·Diego A PizzagalliMaurizio Fava
Sep 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Jonathan PriceGuy M Goodwin
Sep 4, 2009·Biological Psychiatry·Gabriel S DichterMoria J Smoski
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
Oct 23, 2009·Biological Psychiatry·Alexander SartoriusAndreas Meyer-Lindenberg
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alice DobiMarisela Morales
Jan 30, 2010·Neuroscience·G S KranzR Lanzenberger
May 19, 2010·Psychiatry Research·Yulia Chentsova-Dutton, Kaitlin Hanley
Jun 19, 2010·Nature Reviews. Neuroscience·Okihide Hikosaka
Dec 15, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nicole GeschwindMarieke Wichers
Apr 13, 2011·Brain : a Journal of Neurology·Victoria B GradinJ Douglas Steele
May 14, 2011·Journal of Neuroscience Methods·Addy van DijkDamiaan Denys

❮ Previous
Next ❯

Citations

Nov 5, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marie WoelferMartin Walter
Dec 8, 2019·The European Journal of Neuroscience·Gali UmschweifYotam Sagi
Dec 12, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G PetitP de Timary
Mar 3, 2020·Human Brain Mapping·Joana R A LoureiroKatherine L Narr
May 28, 2020·International Clinical Psychopharmacology·Bryant LimSakina J Rizvi
Jul 25, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A KazemiK Djafarian
Sep 12, 2019·Frontiers in Human Neuroscience·Asako MoriSiegfried Kasper
Jun 21, 2020·Translational Psychiatry·Hannah R BogoianVonetta M Dotson
Feb 13, 2019·The International Journal of Neuropsychopharmacology·Siegfried Kasper, Alan Frazer
Jul 26, 2019·Psychopharmacology·Yumiko IkedaHidenori Suzuki
May 14, 2020·Neural Plasticity·Ella E BauerPeter J Clark
Sep 16, 2020·Molecular Psychiatry·Anahit MkrtchianCarlos A Zarate
Nov 23, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Chao XieUNKNOWN IMAGEN Consortium
Mar 4, 2021·Neuropsychiatric Disease and Treatment·Roger S McIntyreMichael Cronquist Christensen
Feb 23, 2021·Psychiatry Research·Linas WilkialisRoger S McIntyre
Mar 16, 2021·Pain and Therapy·Laxmaiah ManchikantiJoshua A Hirsch
Jun 17, 2020·Diabetes & Metabolic Syndrome·Mahua Jana DubeySouvik Dubey
Apr 4, 2021·Journal of Clinical Medicine·Byung-Hoon KimJae-Jin Kim
May 15, 2021·Frontiers in Psychiatry·Ajay SarawagiAnant Bahadur Patel
Jun 3, 2021·Cells·Elena V FilatovaPetr A Slominsky
May 25, 2021·Journal of Affective Disorders·Michele SchmitterAlbertine J Oldehinkel
Jun 18, 2021·Cognitive, Affective & Behavioral Neuroscience·Vonetta M DotsonAndrew M Gradone
Jul 2, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ywlliane da Silva Rodrigues MeurerRegina Helena Silva
Aug 26, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiang LiHui-Li Jiang
Oct 14, 2021·Social Cognitive and Affective Neuroscience·Jessica BomyeaCharles Taylor
Jan 8, 2022·Harvard Review of Psychiatry·David S Thylur, David R Goldsmith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.