PMID: 8610179Apr 2, 1996Paper

Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys

Proceedings of the National Academy of Sciences of the United States of America
A H GazzaleyJ H Morrison

Abstract

Age-associated memory impairment occurs frequently in primates. Based on the established importance of both the perforant path and N-methyl-D-aspartate (NMDA) receptors in memory formation, we investigated the glutamate receptor distribution and immunofluorescence intensity within the dentate gyrus of juvenile, adult, and aged macaque monkeys with the combined use of subunit-specific antibodies and quantitative confocal laser scanning microscopy. Here we demonstrate that aged monkeys, compared to adult monkeys, exhibit a 30.6% decrease in the ratio of NMDA receptor subunit 1 (NMDAR1) immunofluorescence intensity within the distal dendrites of the dentate gyrus granule cells, which receive the perforant path input from the entorhinal cortex, relative to the proximal dendrites, which receive an intrinsic excitatory input from the dentate hilus. The intradendritic alteration in NMDAR1 immunofluorescence occurs without a similar alteration of non-NMDA receptor subunits. Further analyses using synaptophysin as a reflection of total synaptic density and microtubule-associated protein 2 as a dendritic structural marker demonstrated no significant difference in staining intensity or area across the molecular layer in aged animals compa...Continue Reading

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Citations

Jun 22, 2000·The Journal of Comparative Neurology·D A MerrillM H Tuszynski
Oct 12, 2000·Diabetes/metabolism Research and Reviews·C M Ryan, M Geckle
Dec 6, 2001·Hippocampus·J W Newcomer, J H Krystal
Jul 31, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Chiara RistoriPaola Bagnoli
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Shu-Chen Li, Hubert R Dinse
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Alan Peters
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
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Jan 30, 2004·Neurobiology of Aging·Ling BaiKathy R Magnusson
Dec 9, 1997·Neurobiology of Aging·A H GazzaleyJ H Morrison
May 30, 1998·Neuroscience Letters·K ShimazakiK Watanabe
May 29, 2002·Neuroscience·A GazzaleyD L Benson
Nov 14, 2000·Journal of Chemical Neuroanatomy·D P PerlP R Hof
Feb 25, 2005·Behavioral Neuroscience·Agnès LacreuseJames G Herndon
May 7, 2002·The Australian and New Zealand Journal of Psychiatry·P S Sachdev
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael A YassaCraig E L Stark
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