Circular dichroism of biological macromolecules
Circular dichroism, the unequal absorption of right and left circularly polarized light, is a manifestation of optical activity in the vicinity of absorption bands. To the experimental scientist interested in the conformation of macromolecules and in the sensitive response of optical activity to conformational alteration, it offers a relatively new and powerful means of understanding the environment of chromophoric residues. As a tool in the elucidation of electronic spectra, it should be useful to the theoretical scientist in identifying weakly allowed absorption bands as well as in providing rotational parameters which can be compared with the developing theory of optical activity. I have stressed application of circular dichroism, to experimental aspects of protein and nucleic acid conformation in solution. Much is still uncertain in particular quantitative details. However, even these early results shed new light and yield new information on the conformation of these molecules.
The circular dichroism of aromatic polypeptides: theoretical studies of poly-L-phenylalanine and some para-substituted derivatives
Effect of diisopropylfluorophosphate, edrophonium and a stabilizing agent on the conformation of acetylcholinesterase
Spectroscopic determination of lysozyme conformational changes in the presence of trehalose and guanidine
Resolution of independently titrating spectral components in the ultraviolet circular dichroism of subtilisin enzymes by matrix rank analysis
Circular dichroism of crystalline L-cystine in potassium bromide disc. Possibility of exciton splitting
Further studies on the circular dichroism of carboxypeptidase A (ANSON). Reduced-monoalkylated carboxypeptidase A, and carboxypeptidase Aalpha, Abeta, and Agamma
Further characterization studies of the alpha-amylase protein inhibitor of gel electrophoretic mobility 0.19 from the wheat kernel
Polymorphism in fowl serum albumin. I. Characterization of two genetic variants of fowl serum albumin and definition of peptide differences
High-level synthesis in Escherichia coli of shortened and full-length human acidic fibroblast growth factor and purification in a form stable in aqueous solutions
Changes of tyrosine and tryptophan residues in human hemoglobin by oxygen binding: near- and far-UV circular dichroism of isolated chains and recombined hemoglobin
The electrochemically induced conformational transition of disulfides in bovine serum albumin studied by thin layer circular dichroism spectroelectrochemistry
Solid state optical activity of dichalcogenides: isolation by chiral crystallization and determination of absolute configuration
Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions
On the structure of human serum high-density lipoprotein: studies by the technique of circular dichroism
A model for protein biosynthesis predicated on the concept of metastable states: a postulated role for genetic code degeneracy
Muscle beta-actinin and serum albumin of the chicken are indistinguishable by physicochemical and immunological criteria
Extended binding site on fibronectin for the functional upstream domain of protein F1 of Streptococcus pyogenes.
Spectroscopic studies on effector-induced and substrate-induced conformation changes of phosphofructokinase
Recombinant-DNA-derived bovine growth hormone from Escherichia coli. 2. Biochemical, biophysical, immunological and biological comparison with the pituitary hormone
The circular dichroism of synaptosomal membranes: studies of interactions with neuropharmacological agents
Comparison of the protein conformations between different forms (Pr and Pfr) of native (124 kDa) and degraded (118/114 kDa) phytochromes from Avena sativa
Far-ultraviolet optical rotatory dispersion and circular dichroism studies of bovine pancreatic ribonuclease A
Regeneration of native structure and biological activity by air oxidation of reduced pancreatic secretory trypsin inhibitor and Des-Thr-Ser-Pro-Gln-Arg-inhibitor
Small molecule-macromolecular interactions as studied by optical rotatory dispersion--circular dichroism
Assessing the Utility of Circular Dichroism and FTIR Spectroscopy in Monoclonal-Antibody Comparability Studies
The topology, in model membranes, of the core peptide derived from the T-cell receptor transmembrane domain
Comparative study of flavins binding with human serum albumin: a fluorometric, thermodynamic, and molecular dynamics approach
Optical rotatory dispersion and circular dichroism studies on insulin and its trypsin-modified derivatives
The optical activity of plasma membranes and its modification by lysolecithin, phospholipase A and phospholipase C
Conformational analysis of a snake neurotoxin by prediction from sequence, circular dichroism, and raman spectroscopy
The kinetics of dissociation and reassociation of ovine pituitary interstitial cell stimulating hormone
Comparison of CD spectra in the aromatic region on a series of variant proteins substituted at a unique position of tryptophan synthase alpha-subunit
Subunit interactions of rabbit muscle aldolase. Conformational change of aldolase in magnesium chloride and its relationship to the dissociation of subunits
Conformational change of pepsin induced by its substrate N-acetyl-L-phenylalanyl-L-3,5-diiodotyrosine
Circular dichroism studies on effects of organic solvents on conformation and inhibitory capacity of soybean trypsin inhibitor
An easy 'Filter-and-Separate' method for enantioselective separation and chiral sensing of substrates using a biomimetic homochiral polymer
The measurement of binding constants using circular dichroism. Binding of phenylbutazone and oxyphenbutazone
Structural features of gamma-immunoglobulin, antibody, and their fragments. Circular dichroism studies
Nucleic acid-small molecule interactions. VII. Further characterization of deoxyribonucleic acid-diamino steroid complexes
Equine antihapten antibody. Studies on the primary structure and conformation of equine immunoglobulins
Circular dichroic and optical rotatory dispersion spectra of the threonine-inhibited aspartokinase-homoserine dehydrogenase of Escherichia coli K 12. Effects of ligand binding and protein denaturation
Circular dichroism and the conformations of membrane proteins. Studies with red blood cell membranes
Conformational changes in proteins as measured by difference sedimentation studies. I. A technique for measuring small changes in sedimentation coefficient
Selective tryptophan oxidation in the antitumor protein neocarzinostatin and effects on conformation and biological activity
Comparative studies of the single tryptophan residue in human chorionic somatomammotropin and human pituitary growth hormone
Zinc binding, circular dichroism, and equilibrium sedimentation studies on insulin (bovine) and several of its derivatives
beta Structure of aqueous staphylococcal enterotoxin B by spectropolarimetry and sequence-based conformational predictions
Spectroscopic and kinetic analysis of a monoclonal IgG cryoglobulin. Effect of mild reduction on cryoprecipitation
Circular dichroism, Raman spectroscopy, and gel filtration of trapped folding intermediates of ribonuclease
Structural analysis of staphylococcal enterotoxins B and C1 using circular dichroism and fluorescence spectroscopy
Inhibition of α-amylase Activity by Zn2+ : Insights from Spectroscopy and Molecular Dynamics Simulations
A computational approach to get insights into multiple faces of additives in modulation of protein aggregation pathways
Induction, control, and rationalization of supramolecular chirogenesis using metalloporphyrin tweezers: a structure-function correlation
Ligand induced conformational changes in various normal and modified hemoglobins as indicated by changes in optical rotatory dispersion
Conformation of antibiotic protein, neocarzinostatin, studied by plane polarized infrared spectroscopy, circular dichroism and optical rotatory dispersion
Circular dichroic and fluoropolarimetric studies on tryptophyl residues in acid-induced isomerization of bovine plasma albumin
Circular dichroism spectra of trypsin and chymotrypsin complexes with Bowman-Birk or chickpea trypsin inhibitor
Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system
Broadband Linear-to-Circular Polarization Conversion Enabled by Birefringent Off-Resonance Reflective Metasurfaces
Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR
A novel amalgamation of deep eutectic solvents and crowders as biocompatible solvent media for enhanced structural and thermal stability of bovine serum albumin
High-throughput screening of identity, enantiomeric excess, and concentration using MLCT transitions in CD spectroscopy
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