Circular RNA ABCB10 correlates with advanced clinicopathological features and unfavorable survival, and promotes cell proliferation while reduces cell apoptosis in epithelial ovarian cancer

Cancer Biomarkers : Section a of Disease Markers
Yan ChenXuefang Lin

Abstract

This study aimed to explore the correlation of circular RNA ABCB10 (circ-ABCB10) expression with clinicopathological features and survival, as well as its impact on regulating cell proliferation and apoptosis in epithelial ovarian cancer (EOC). A total of 103 EOC patients were consecutively recruited, then their tumor tissues were obtained for circ-ABCB10 detection using qRT-PCR. Additionally, 53 EOC adjacent tissues were collected as control. Patients' clinicopathological and survival data were recorded. In vitro, circ-ABCB10 expression was detected in OVCAR3, UWB1.289, SKOV3, CAOV3 and IOSE80 cell lines by RT-qPCR, and the effect of circ-ABCB10 on cell proliferation and apoptosis was detected through circ-ABCB10 overexpression and silencing by plasmids transfection into SKOV3 cells. Circ-ABCB10 was upregulated in tumor tissues compared with adjacent tissues, and presented with good value in distinguishing tumor tissues from adjacent tissues (AUC = 0.766, 95% CI: 0.690-0.842). Circ-ABCB10 high expression was correlated with poor differentiation, large tumor size and advanced International Federation of Gynecology and Obstetrics (FIGO) stage in EOC patients. As for survival, circ-ABCB10 was correlated with worse OS. In vitro ex...Continue Reading

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Citations

Feb 13, 2020·The Journal of Obstetrics and Gynaecology Research·Xiaofeng SunYuqiang Gao
Jun 27, 2020·Cancer Cell International·Xuejing YangChaoying Liu
Mar 23, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bowen LiuYunfu Cui
May 21, 2021·DNA and Cell Biology·Kena ZhouShiwei Duan
Oct 17, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jason R Brown, Arul M Chinnaiyan
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Yalan MaYing Xu
Sep 25, 2021·Cellular & Molecular Biology Letters·Zahra ForuzandehMohammad Reza Alivand

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