Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Ebrahim MahmoudiMurray J Cairns

Abstract

Circular RNAs (circRNAs) are a covalently closed subclass of non-coding RNA molecules formed by back splicing of linear precursor RNA. These molecules are relatively stable and particularly abundant in the mammalian brain and therefore may participate in neural development and function. With the emergence of circRNAs activity in gene regulation, these molecules have been implicated in several biological processes, including synaptic plasticity, and we therefore suspect they may have a role in neurobehavioral disorders. Here, we profile cortical circRNAs expression in 35 postmortem cortical gray matter (BA46) schizophrenia and a non-psychiatric comparison group, using circRNA enrichment sequencing. While more than 90,000 circRNAs species were identified in the dorsolateral prefrontal cortex (DLPFC), we observed lower complexity and substantial depletion in subjects with the disorder. Although circRNAs expression was independent of their host gene transcription, alternative splicing rates were lower in samples from cases compared to controls. Gene set analysis of differentially expressed circRNAs host genes revealed significant enrichment of neural functions and neurological disorders. Many of these depleted circRNAs are also pre...Continue Reading

References

Jan 8, 2004·Genome Biology·Anton J EnrightDebora S Marks
Dec 13, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Karolina AbergElena Jazin
Apr 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Karolina AbergElena Jazin
Sep 20, 2006·Neuron·Michael A Kiebler, Gary J Bassell
Jul 7, 2007·Molecular Cell·Andrew GrimsonDavid P Bartel
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
Oct 18, 2007·BMC Bioinformatics·Jing ChenAnil G Jegga
Sep 2, 2009·Molecular Psychiatry·N J BeveridgeM J Cairns
Jan 16, 2010·The Australian and New Zealand Journal of Psychiatry·Cynthia Shannon WeickertClive Harper
Jan 1, 2006·Indian Journal of Psychiatry·J K Trivedi
Jun 24, 2011·Bioinformatics·Adam RobertsLior Pachter
Oct 11, 2011·Human Molecular Genetics·Gilad SilberbergMarie Öhman
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Mar 1, 2013·Nature·Sebastian MemczakNikolaus Rajewsky
Sep 17, 2013·Molecular Cell·Yang ZhangLing-Ling Chen
May 9, 2014·Nature Biotechnology·William R Jeck, Norman E Sharpless
Sep 23, 2014·RNA·Petar GlažarNikolaus Rajewsky
Sep 23, 2014·Molecular Cell·Reut Ashwal-FlussSebastian Kadener
Sep 23, 2014·Cell·Xiao-Ou ZhangLi Yang
Aug 1, 2010·Current Directions in Psychological Science·Katherine H KarlsgodtTyrone D Cannon
Jan 6, 2015·Cell Reports·Andranik IvanovNikolaus Rajewsky
Mar 15, 2015·Cell·Simon J ConnGregory J Goodall
Apr 30, 2015·Molecular Cell·Agnieszka Rybak-WolfNikolaus Rajewsky
May 16, 2015·Nucleic Acids Research·Ioannis S VlachosArtemis G Hatzigeorgiou
Jul 15, 2015·Biochimica Et Biophysica Acta·Karoline K EbbesenThomas B Hansen
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Feb 16, 2016·Molecular Cell·Wen XiaoYun-Gui Yang
Feb 26, 2016·Nature Reviews. Molecular Cell Biology·Ling-Ling Chen
Jun 19, 2016·Progress in Neurobiology·Sharon L Hollins, Murray J Cairns
Jun 24, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jocelyn WidagdoTimothy W Bredy
Aug 12, 2016·Scientific Reports·Tim SchneiderAlbrecht Bindereif
Sep 14, 2016·Molecular Psychiatry·E Mahmoudi, M J Cairns
Dec 3, 2016·Nucleic Acids Research·UNKNOWN The Gene Ontology Consortium

❮ Previous
Next ❯

Citations

Jun 17, 2020·Journal of Cellular Physiology·Guifeng TanZhonglin Liu
Jul 2, 2020·Journal of Clinical Laboratory Analysis·Yu ZhangXu Zhang
Jan 29, 2020·Molecular Psychiatry·Amber J ZimmermanNikolaos Mellios
May 28, 2020·Frontiers in Psychiatry·Zexuan LiYong Xu
Apr 23, 2020·International Journal of Oncology·Yuhao ZhangHong Wang
Aug 6, 2020·Cells·Silvia GaspariniCecilia Mannironi
Oct 10, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Esmi L Zajaczkowski, Timothy W Bredy
Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hua GanJiaxu Chen
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiwei YangBurton B Yang
Feb 10, 2021·Cellular and Molecular Life Sciences : CMLS·Kaiyu XuJiali Li
Mar 31, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ebrahim MahmoudiMurray J Cairns
Jun 12, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hailei YuChunling Ma
Sep 3, 2021·Neural Regeneration Research·Yu-Qi ChengZheng-Bu Liao

❮ Previous
Next ❯

Methods Mentioned

BETA
CLIP-seq
RNA-Seq
chips
electrophoresis
PCR
RNAseq
circRNA

Software Mentioned

circRNAs
TopHat2
CIRCexplorer
find
circ
getfasta
Cufflinks
CIRCexplorer2
Bowtie
TopHat

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.