Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway

Journal of Cellular Physiology
Z ZengYi Yu

Abstract

Increasing reports indicate that circular RNAs (circRNAs) are very important regulators in human diseases, including cancers. In bladder cancer (BC), several circRNAs have been reported to be involved in tumor progressions, such as circ-ITCH and circTCF25. However, the functions of most circRNAs in BC still remains largely unknown. In this study, we identified a novel circRNA termed as circ-VANGL1 by bioinformatics analysis. We found that circ-VANGL1 was highly expressed in BC tissues compared with adjacent normal tissues. Furthermore, we showed that circ-VANGL1 could serve as a prognostic marker for patients with BC. Through functional experiments, we found that circ-VANGL1 knockdown significantly suppressed BC cell proliferation, cell cycle, migration, and invasion in vitro. Besides, circ-VANGL1 silence inhibited BC cell propagation in vivo. Mechanistically, we identified circ-VANGL1 as a sponge of miR-605-3p which targeted VANGL1 in BC cells. Through repressing miR-605-3p availability, circ-VANGL1 contributes to VANGL1 expression, consequently leading to BC cell proliferation, migration, and invasion. Taken together, our study demonstrated circ-VANGL1/miR-605-3p/VANGL1 as a novel essential signaling pathway involved in BC pr...Continue Reading

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Citations

May 17, 2019·Journal of Cellular Physiology·Naijie LiuZhigang Guo
May 8, 2020·Journal of Cellular and Molecular Medicine·Yao LiuYang Zhao
May 22, 2020·Journal of Cellular and Molecular Medicine·Yi-Lin HuWan-Jiang Xue
Sep 11, 2020·Computational and Mathematical Methods in Medicine·Yunhao SunHaitao Ma
Jun 18, 2020·Cancer Management and Research·Changjiu LiLugeng He
Dec 19, 2019·Frontiers in Genetics·Victor G MartinezJesus Maria Paramio
Oct 9, 2020·Genetic Testing and Molecular Biomarkers·Siyuan WangTing Sun
Oct 12, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dandan LiJinming Li
Jan 12, 2021·Molecular Therapy. Nucleic Acids·Tong ShaoXing-Dong Xiong
Oct 17, 2020·OncoTargets and Therapy·Zhonglin Cai, Hongjun Li
Jan 26, 2021·Frontiers in Oncology·Zhaofeng LiangHui Qian
Feb 5, 2021·Frontiers in Oncology·Xiong WangLiming Cheng
Mar 2, 2021·Frontiers in Oncology·Xiong WangLiming Cheng
Aug 6, 2021·Frontiers in Cell and Developmental Biology·Fajuan ChengWei He
Feb 10, 2020·Molecular Therapy. Nucleic Acids·Xuemei ShenHong Chen

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