Circular RNA circSLC25A16 contributes to the glycolysis of non-small-cell lung cancer through epigenetic modification.

Cell Death & Disease
Hong ShangguanXingwen Wang

Abstract

Growing evidence has highlighted the roles of circular RNAs (circRNAs) in non-small-cell lung cancer (NSCLC), however, their roles in NSCLC glycolysis remains poorly understood. CircRNAs microarray profiles discovered a novel exon-derived circRNA, circSLC25A16 (hsa_circ_0018534), in NSCLC tissue samples. In NSCLC samples, high-expression of circSLC25A16 was associated with unfavorable prognosis. Cellular experiments revealed that circSLC25A16 accelerated the glycolysis and proliferation of NSCLC cells. Besides, circSLC25A16 knockdown repressed the in vivo growth by xenograft assays. RNA-fluorescence in situ hybridization (RNA-FISH) illustrated that circSLC25A16 and miR-488-3p were both located in cytoplasm. Mechanistic experiments demonstrated that circSLC25A16 interacts with miR-488-3p/HIF-1α, which activates lactate dehydrogenase A (LDHA) by facilitating its transcription. Collectively, present research reveals the crucial function of circSLC25A16 on NSCLC glycolysis through miR-488-3p/HIF-1α/LDHA, suggesting the underlying pathogenesis for NSCLC and providing a therapeutic strategy for precise treatment.

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Citations

Jan 29, 2021·International Journal of Molecular Sciences·Dexter L PuckettAhmed Bettaieb
Apr 16, 2021·OncoTargets and Therapy·Tan LiXin-Hua Liang
Jun 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammadreza Hajiesmaeili
Jul 30, 2021·Drug Discovery Today·Zi-Xian LiaoPan-Chyr Yang

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Methods Mentioned

BETA
surgical resection
PCR
Assay
immunoprecipitation
xenografts
xenograft
transfection
ChIP

Software Mentioned

JASPAR
Image Studio

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