Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Qi ChenBo Yu

Abstract

Dendritic cells (DCs) can orchestrate either immunogenic or tolerogenic responses to relay information on the functional state. Emerging studies indicate that circular RNAs (circRNAs) are involved in immunity; however, it remains unclear whether they govern DC development and function at the transcriptional level. In this study, we identified a central role for a novel circRNA, circSnx5, in modulating DC-driven immunity and tolerance. Ectopic circSnx5 suppresses DC activation and promotes the development of tolerogenic functions of DCs, while circSnx5 knockdown promotes their activation and inflammatory phenotype. Mechanistically, circSnx5 can act as a miR-544 sponge to attenuate miRNA-mediated target depression on suppressor of cytokine signaling 1 (SOCS1) and inhibit nuclear translocation of PU.1, regulating DC activation and function. Furthermore, the main splicing factors (SFs) were identified in DCs, of which heterogeneous nuclear ribonucleoprotein (hnRNP) C was essential for circSnx5 generation. Moreover, our data demonstrated that vaccination with circSnx5-conditioned DCs prolonged cardiac allograft survival in mice and alleviated experimental autoimmune myocarditis. Taken together, our results revealed circSnx5 as a key...Continue Reading

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Citations

Mar 27, 2021·Molecular Therapy. Nucleic Acids·Xin WangYuling Shi
May 22, 2021·Signal Transduction and Targeted Therapy·Alina T HeBurton B Yang
Jun 3, 2021·International Journal of Molecular Sciences·Chisato KinoshitaKoji Aoyama
May 31, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Bowen WangXiufen Zheng
Jul 13, 2021·Frontiers in Cardiovascular Medicine·Tiqun YangZhan-Peng Huang
Aug 28, 2021·Molecular Medicine·Mei TaoShaoqing Ju
Oct 21, 2021·Chinese Medical Journal·Yi-Ping TangYu-Feng Qing

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