Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

Cell Death & Disease
Wei GuoYong-Jin Li

Abstract

Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.

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Citations

Apr 28, 2019·Journal of Biomedical Science·Chun-Ying Yu, Hung-Chih Kuo
Apr 29, 2019·Journal of Translational Medicine·Xubin QiuJinbo Liu
Jun 9, 2020·Experimental and Therapeutic Medicine·Yong JiangZhao-Fan Xia
Oct 18, 2019·Cell Proliferation·Zheng LiWilliam K K Wu
Apr 7, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Xue-Qiang WangPei-Jie Chen
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiwei YangBurton B Yang
Oct 5, 2021·Experimental and Therapeutic Medicine·Zhidi LinJianyuan Jiang

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Datasets Mentioned

BETA
GPL19449

Methods Mentioned

BETA
chip
transfection
PCR
Assay

Software Mentioned

affy
limma
RCircos
R
TargetScan
DAVID
of
miRanda
Cytoscape
SPSS

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis