Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells

Epigenomics
Shanliang ZhongJifeng Feng

Abstract

We aimed to explore the roles of circRNAs in gastric cancer. The dysregulated circRNAs and miRNAs were identified using data from Gene Expression Omnibus. The roles of specifically selected circRNAs were explored. Survival analysis was performed using data from the Cancer Genome Atlas. We identified 68 dysregulated circRNAs and 51 dysregulated miRNAs. We found that hsa_circ_0000993 inhibited migration, invasion and proliferation of gastric cancer cells and could act as a miRNA sponge for miR-214-5p but did not modulate expression of its parental gene, ATL2. Survival analysis showed that gastric cancer patients with lowly expressed miR-214-5p had a significantly better overall survival. In conclusion, hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p.

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Citations

Oct 21, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Min LiuShanliang Zhong
Aug 21, 2019·Biotechnology Letters·Shanliang ZhongJifeng Feng
Jan 11, 2020·Expert Review of Gastroenterology & Hepatology·Yao RuanJunming Guo
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May 19, 2020·Journal of Clinical Laboratory Analysis·Yezhao WangJunming Guo
Jun 23, 2020·Oncology Letters·Chun-Mei YangLi-Jun Ma
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Oct 20, 2020·Frontiers in Oncology·Wei WuQingli Yang
Jul 28, 2020·Cancer Letters·Shanshan XieTianhua Zhou

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Datasets Mentioned

BETA
GSE78092
GSE78091
GPL19978

Methods Mentioned

BETA
PCR
Assay
miRNA-seq
transfection

Software Mentioned

limma
RNAhybrid
R
circRNA
Cytoscape
Ensemble
miRanda
edgeR

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