Circular RNA of vimentin expression as a valuable predictor for acute myeloid leukemia development and prognosis

Journal of Cellular Physiology
Yun-Yun YiZhao-Qun Deng

Abstract

The focus of this study was to investigate the expression status of Circ-vimentin (VIM) and further analyze its pathogenesis and clinical significance in acute myeloid leukemia (AML) patients. Real-time quantitative polymerase chain reaction was carried on Circ-VIM in 113 AML patients and 42 healthy controls. Circ-VIM was significantly upregulated in AML compared with control and was positively correlated with white blood cells (WBC) count. Receiver operating characteristic curve analysis indicated that the performance of Circ-VIM expression could serve as a promising biomarker for differentiating AML patients from controls. Significant correlations of Circ-VIM expression were found with WBC and French-American-British classifications. Survival analyses further showed that over-expressed Circ-VIM were associated with markedly shorter overall survival (OS) and leukemia-free survival (LFS) in whole-cohort AML, nonacute promyelocytic leukemia AML and cytogenetically normal-AML patients. Multivariate analysis also disclosed that Circ-VIM over-expression was an independent poor prognostic factor for OS and LFS in AML patients. Remarkably, Pearson correlation analysis evidenced that the expression of Circ-VIM was positively correlate...Continue Reading

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Citations

Sep 11, 2020·Journal of Leukocyte Biology·Lei FuYewei Wang
Jan 16, 2020·Molecular Cancer·Zhonghua MaJiafu Ji
Nov 22, 2018·Journal of Molecular Neuroscience : MN·Zheng HaoMeihua Li
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Jan 10, 2021·Cancers·Irina A Elcheva, Vladimir S Spiegelman
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Sabah NisarMohammad Haris
Jul 8, 2020·Genomics·Zhi LinMinghua Yang

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