Circular RNA profile of infantile hemangioma by microarray analysis

PloS One
Cong FuRan Huo

Abstract

Circular RNAs (circRNAs) are a recently identified class of noncoding RNAs that participate in several physiological processes. However, the expression of circRNAs in infantile hemangioma (IH) remains unknown. The profile of circRNAs was assessed by microarray in four pairs of IH and adjacent skin tissues. The expression of circRNAs was validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Furthermore, circRNA-microRNAs (miRNA)-mRNA networks were constructed using bioinformatics tools. 234 up- and 374 down- regulated circRNAs were identified in IH by microarray. Among them, the expression of two up-regulated circRNAs (hsa_circRNA_100933 and hsa_circRNA_100709) and one down-regulated circRNA (hsa_circRNA_104310) was confirmed by qRT-PCR. In addition, 3,019 miRNA response elements (MREs) of circRNAs were predicted, and two circRNA-miRNA-mRNA networks were constructed, including 100 and 94 target genes of hsa_circRNA_100933 and hsa_circRNA_104310, respectively. GO and pathway analysis showed that both networks participated in angiogenesis and vascular development-related biological processes. This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterizati...Continue Reading

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Citations

Jun 20, 2018·Cancer Biomarkers : Section a of Disease Markers·Jian ZhouWeiwei Tang
Jun 13, 2021·Cancer Cell International·Jiabin YuHongting Lu
Jul 25, 2021·International Journal of Molecular Sciences·Rok RazpotnikTadeja Režen
Sep 10, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marina C CostaRocío Toro

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Datasets Mentioned

BETA
GSE93522
18429863

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

miRWalk
Database for Annotation , Visualization , and Integrated Disco...
TargetScan
DAVID
miRanda
KOBAS
Microsoft Office
limma
GraphPad Prism
Cytoscape

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