Circular RNAs Are Regulators of Diverse Animal Transcriptomes: One Health Perspective

Frontiers in Genetics
Dora Zucko, Kathleen Boris-Lawrie

Abstract

Derived from linear (parental) precursor mRNA, circRNA are recycled exons and introns whose ends are ligated. By titrating microRNAs and RNA binding proteins, circRNA interconnect networks of competing endogenous RNAs. Without altering chromosomal DNA, circRNA regulates skeletal muscle development and proliferation, lactation, ovulation, brain development, and responses to infections and metabolic stress. This review integrates emerging knowledge of circRNA activity coming from genome-wide characterizations in many clades of animals. circRNA research addresses one of the main pillars of the One Health vision - to improve the health and productivity of food animals and generate translational knowledge in animal species.

References

Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H L SangerA K Kleinschmidt
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D D Von HoffG M Wahl
Apr 1, 1991·The Journal of General Virology·L N PayneM E Thouless
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T O Diener
Jun 24, 1985·Biochimica Et Biophysica Acta·P D Baas
Jan 1, 1968·Cold Spring Harbor Symposia on Quantitative Biology·W Gilbert, D Dressler
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D Dressler
Jul 3, 2003·Journal of Dairy Science·J W West
May 15, 2010·The Journal of Veterinary Medical Science·Ziqiang ChengLi Zhang
Aug 31, 2010·Nucleic Acids Research·Kai WangJinze Liu
Sep 14, 2010·Preventive Veterinary Medicine·J ZinsstagM Tanner
Dec 22, 2011·International Journal of Epidemiology·C H Waddington
Feb 22, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Salomé S PinhoFátima Gärtner
Aug 22, 2012·Bioinformatics·Johannes Köster, Sven Rahmann
Nov 20, 2012·Veterinary Microbiology·Qi WangXiaomei Wang
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Mar 1, 2013·Nature·Sebastian MemczakNikolaus Rajewsky
Mar 26, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Wen LuoXiquan Zhang
Sep 17, 2013·Molecular Cell·Yang ZhangLing-Ling Chen
Sep 17, 2013·PLoS Genetics·Julia SalzmanPatrick O Brown
Dec 18, 2013·Frontiers in Genetics·Suman GhosalJayprokas Chakrabarti
Mar 13, 2014·PloS One·Peter L WangJulia Salzman
Mar 25, 2014·World Journal of Gastroenterology : WJG·John M Taylor
May 9, 2014·Nature Biotechnology·William R Jeck, Norman E Sharpless
Sep 23, 2014·RNA·Petar GlažarNikolaus Rajewsky
Nov 19, 2014·RNA·Erika Lasda, Roy Parker
Jan 6, 2015·Cell Reports·Andranik IvanovNikolaus Rajewsky
Apr 30, 2015·Molecular Cell·Agnieszka Rybak-WolfNikolaus Rajewsky
May 20, 2015·Veterinary and Comparative Oncology·J HicksA Haley
Jun 25, 2015·Microbiology Spectrum·J A Ruiz-MasóG Del Solar
Aug 11, 2015·BioMed Research International·Mao NieDa-Zhi Wang
Oct 10, 2015·Nucleic Acids Research·Yu-Chen LiuHsien-Da Huang

❮ Previous
Next ❯

Citations

Apr 4, 2021·International Journal of Molecular Sciences·Duy N DoEveline M Ibeagha-Awemu
Apr 11, 2021·Methods : a Companion to Methods in Enzymology·Amanda Yunn Ee Ng, Jun Wei Pek
Jun 7, 2021·Environmental Science and Pollution Research International·Xiaoyan LiHengxi Wei

❮ Previous
Next ❯

Methods Mentioned

BETA
RNAseq
RNA-seq
CircleSeq
circRNAseq
RNA seq
RAP

Software Mentioned

MapSplice
circRNA
HiSat2
CircleSeq
find
NCLscan
Bowtie
circRNAseq
Snake Make
circ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved