Circular RNAs are temporospatially regulated throughout development and ageing in the rat

Scientific Reports
Ebrahim Mahmoudi, Murray J Cairns

Abstract

Circular RNAs (circRNAs) are covalently closed structural isoforms of linear mRNA which have been observed across a broad range of species and tissues. Here, we provide a comprehensive circRNAs expression catalogue for the rat including 8 organs of both sexes during 4 developmental stages using a public RNAseq dataset. These analyses revealed thousands of circular RNA species, many expressed in an organ-specific manner along with their host genes which were enriched with tissue-specific biological functions. A large number of circRNAs also displayed a developmental-dependent expression pattern and are accumulated during ageing. CircRNAs also displayed some sexually dimorphic expression, with gender associated differences observed in various tissues and developmental stages. These observations suggest that circRNAs are dynamically expressed in a spatial-, temporal- and gender-specific manner in mammals, and may have important biological function in differentiation, development and aging.

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Citations

Apr 11, 2019·American Journal of Physiology. Cell Physiology·Zhiwen LiuZheng Dong
Jan 31, 2020·Frontiers in Molecular Biosciences·Ashirbad GuriaGopal Pandi
Apr 26, 2020·International Journal of Molecular Sciences·Maria P YavropoulouPolyzois Makras
Jun 27, 2020·Frontiers in Cell and Developmental Biology·Heather BranscomeFatah Kashanchi
Aug 6, 2020·Cells·Silvia GaspariniCecilia Mannironi
Jan 13, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Stylianos RavanidisEpaminondas Doxakis
Feb 10, 2021·Cellular and Molecular Life Sciences : CMLS·Kaiyu XuJiali Li
Mar 31, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ebrahim MahmoudiMurray J Cairns
May 22, 2021·Trends in Genetics : TIG·Eunah KimSeung-Jae V Lee
Jul 25, 2021·International Journal of Molecular Sciences·Rok RazpotnikTadeja Režen
Jul 20, 2021·Neurochemistry International·Suresh L MehtaRaghu Vemuganti
Aug 28, 2021·Cancers·Katherine Louise HarperAdrian Whitehouse

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Datasets Mentioned

BETA
GSE53960

Methods Mentioned

BETA
RNA-Seq
RNAseq
CircleSeq

Software Mentioned

TopHat
Cytoscape
CIRCexplorer
CircleSeq
miRanda
Fusion
TargetScan
sratoolkit
Fastq

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