Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics

Frontiers in Molecular Biosciences
Anuva RajappaPiyush Khandelia

Abstract

Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer.

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Citations

Jan 29, 2021·International Journal of Molecular Sciences·Dexter L PuckettAhmed Bettaieb
Mar 12, 2021·Frontiers in Medicine·Jiang ZhouZhangui Tang
Apr 3, 2021·European Journal of Clinical Investigation·Yueqing WangXueling Wei
Jun 7, 2021·Environmental Science and Pollution Research International·Xiaoyan LiHengxi Wei
Aug 14, 2021·Frontiers in Cell and Developmental Biology·Fan ChaoGang Chen
Sep 5, 2021·World Journal of Surgical Oncology·Sepideh KadkhodaAbbas Shakoori
Sep 21, 2021·Frontiers in Cell and Developmental Biology·Yan LiYiquan Ke
Oct 27, 2021·Briefings in Bioinformatics·Enrico GaffoStefania Bortoluzzi

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Methods Mentioned

BETA
chromosomal aberrations
biopsy
antisense oligonucleotides

Software Mentioned

CircCACTIN

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