Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma

PloS One
Gaoyang ChenGuizhen Zhang

Abstract

Osteosarcoma (OS) is a primary malignant bone tumor with a high fatality rate. Many circRNAs have been proved to play important roles in the pathogenesis of some diseases. However, the occurrence of circRNAs in OS remains little known. The circular RNA (circRNA) expression file GSE96964 dataset, which included seven osteosarcoma cell lines and one control sample (osteoblast cell line), was downloaded from the Gene Expression Omnibus (GEO) database to explore the potential function of circRNAs in osteosarcoma by competing endogenous RNA (ceRNA) analysis. Three gene expression profiles of OS were downloaded from GEO database and then used for the pathway enrichment analysis, Venn analysis and protein-protein interaction (PPI) network analysis. Real-time qPCR validation and RNA interference were conducted to verify our prediction. Differentially expressed circRNAs between OS and control, including 8 up-regulated and 102 down-regulated circRNAs, were generated and ceRNA analysis for 5 most up-regulated or 5 most down-regulated circRNAs in OS were then performed. The pathway enrichment analysis of gene expression profiles indicated differentially expressed genes (DEGs) of three gene profiles significantly enriched in cell cycle path...Continue Reading

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Citations

Feb 14, 2020·Journal of Cellular Physiology·Yongkun WangJingzhe Zhang
Jul 14, 2019·Journal of Integrative Bioinformatics·Peijing ZhangMing Chen
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Dec 1, 2020·Frontiers in Oncology·Jiamei LiuShengye Liu
Nov 7, 2020·Technology in Cancer Research & Treatment·Rui GuAixin Hu

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Datasets Mentioned

BETA
GSE36001
GSE96964

Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

GeneMANIA
Functional Enrichment analysis tool ( FUNRICH )
Venn
GEO2R
Circular interactome
Cytoscape
DAVID

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