Circular RNAs in Blood Malignancies

Frontiers in Molecular Biosciences
Olivia Perez de AchaMyriam Gorospe

Abstract

Circular (circ)RNAs influence a wide range of biological processes at least in part by interacting with proteins and microRNAs. CircRNAs expressed in the hematopoietic compartment have been increasingly recognized as modulators of physiological and pathological features of hematopoetic stem cell (HSC)-derived populations. In particular, several circRNAs were found to enhance or suppress tumor progression in blood malignancies such as leukemias and lymphomas. Moreover, numerous circRNAs have been proposed to help confer resistance to the conventional treatments used in hematopoietic cancers. Here, we review the most important circRNAs described thus far in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), lymphomas, and multiple myeloma (MM). We discuss the usefulness of circRNAs as diagnostic and prognostic markers and their potential value as therapeutic targets.

References

May 27, 2009·Current Opinion in Hematology·Krzysztof MrózekGuido Marcucci
Apr 13, 2012·The New England Journal of Medicine·Martin SchrappeMartin Zimmermann
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Oct 18, 2013·Leukemia Research·Simona SoveriniNeil P Shah
Sep 6, 2014·British Medical Bulletin·Rebecca E WalkerAndrew D Chantry
Mar 10, 2015·Protein & Cell·Hong Zhou, Rongzhen Xu
Aug 1, 2015·Wiley Interdisciplinary Reviews. RNA·Iju ChenTrees-Juen Chuang
Aug 5, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio PalumboPhilippe Moreau
Oct 16, 2015·The New England Journal of Medicine·Stephen P Hunger, Charles G Mullighan
Dec 15, 2015·Blood·Hervé Dombret, Claude Gardin
May 6, 2016·Frontiers in Molecular Neuroscience·Yiye Shao, Yinghui Chen
May 29, 2016·Chinese Journal of Cancer·Zhi-Jie KangQuentin Liu
Jul 2, 2016·Blood Cancer Journal·I De Kouchkovsky, M Abdul-Hay
Sep 10, 2016·Wiley Interdisciplinary Reviews. RNA·Amaresh C PandaKotb Abdelmohsen
Oct 14, 2016·Leukemia & Lymphoma·Zofia Litwińska, Bogusław Machaliński
Oct 16, 2016·Blood Cancer Journal·A BonizzatoS Bortoluzzi
Nov 15, 2016·The Journal of Clinical Investigation·Daniel W SherbenouBin Liu
Jan 20, 2017·Nature Reviews. Disease Primers·Thomas J KippsKanti Rai
Jan 29, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shijun ChenJunming Guo
Apr 20, 2017·Journal of the National Cancer Institute·Lu Zhang, Jerry W Shay
Oct 4, 2017·Haematologica·Susanne HirschLars Bullinger
Nov 24, 2017·Pathology·Shaoying LiL Jeffrey Medeiros
Mar 21, 2018·BMC Cancer·Miao WangHuijian Wu
Jul 4, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hongli ChenYun Yang
Jul 22, 2018·Leukemia·Laura CicconiFrancesco Lo-Coco
Jul 25, 2018·Molecular and Cellular Biology·Dong-Mei WuYuan-Lin Zheng
Nov 15, 2018·Biochemical and Biophysical Research Communications·Hongqiong FanWei Li

❮ Previous
Next ❯

Citations

Jan 10, 2021·Cancers·Irina A Elcheva, Vladimir S Spiegelman
Mar 7, 2021·Pharmaceuticals·Marcello Francesco LinguaAlessandro Morotti
Mar 7, 2021·Biomolecules·Caterina MancarellaKatia Scotlandi
Apr 4, 2021·International Journal of Molecular Sciences·Princess D RodriguezSeth Frietze

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
chromosomal aberrations
xenograft

Related Concepts

Related Feeds

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

© 2021 Meta ULC. All rights reserved