Circular RNAs in the cardiovascular system

Non-coding RNA Research
Clarissa P C GomesCardiolinc™ network

Abstract

Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs. Recent investigations showed that circRNAs are regulated in the cardiovascular system and participate in its physiological and pathological development. In this review article, we will provide an overview of the role of circRNAs in cardiovascular health and disease. After a description of the biogenesis of circRNAs, we will summarize what is known of the expression, regulation and function of circRNAs in the cardiovascular system. We will then address some technical aspects of circRNAs research, discussing how artificial intelligence may aid in circRNAs research. Finally, the potential of circRNAs as biomarkers of cardiovascular disease will be addressed and directions for future research will be proposed.

Citations

Jan 19, 2019·Experimental Biology and Medicine·Xue GongChunyu Zeng
Jun 27, 2019·Journal of Cellular and Molecular Medicine·Wei ZhangXiang Zhou
Jul 30, 2019·Hypertension·Amela JusicUNKNOWN EU-CardioRNA COST Action (CA17129)
Mar 18, 2020·Wiley Interdisciplinary Reviews. RNA·Rares DrulaIoana Berindan-Neagoe
Mar 23, 2019·Molecular Cancer·Yang GuoLiang Zhou
May 22, 2018·Clinical Science·Clarissa P C GomesUNKNOWN Cardiolinc™ network
Jun 11, 2019·Frontiers in Oncology·Si-Qi ZhengWei Zhang
Feb 26, 2019·Cellular and Molecular Life Sciences : CMLS·Cornelia BraicuIoana Berindan-Neagoe
Mar 23, 2019·Heart Failure Reviews·Abdel Rahman Yousry Afify
Nov 6, 2020·Biological & Pharmaceutical Bulletin·Man LiuChonglin Luan
Jan 13, 2021·Seminars in Cancer Biology·Aferin BeilerliAamir Ahmad
Dec 29, 2020·Frontiers in Pharmacology·Jia LiuJunnan Wang
Feb 25, 2021·The Journal of Microbiology·Zhihao LouBaolei Jia
Feb 23, 2021·Molecular Therapy. Nucleic Acids·Chen YangHaowen Jiang
Jul 1, 2019·Genomics·Ashton Curry-HydeMichael Janitz

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Methods Mentioned

BETA
footprinting
dissection
immunoprecipitation
RNA-seq
Ribo-Seq

Software Mentioned

Circtools
TopHat Fusion
AS
MEM
WebCircRNA
circRNA
FUCHS
Circ2Traits
CIRI
PredcircRNA

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