Circularly permuted TRAIL plus thalidomide and dexamethasone versus thalidomide and dexamethasone for relapsed/refractory multiple myeloma: a phase 2 study

Cancer Chemotherapy and Pharmacology
Yun LengWenming Chen

Abstract

Circularly permuted TRAIL (CPT) has exhibited promising efficacy as a mono-therapy or in combination with thalidomide for patients with multiple myeloma (MM). In this phase 2 study, the safety and efficacy of CPT in combination with thalidomide and dexamethasone (CPT + TD) was evaluated in patients with pretreated relapsed/refractory MM (RRMM). Patients who received at least two previous therapies for MM were randomly assigned at a 2:1 ratio to receive treatment with CPT + TD or thalidomide and dexamethasone (TD). The primary endpoint was the overall response rate (ORR), and the secondary endpoints included progression-free survival (PFS), duration of response (DOR) and safety. Overall, 47 patients were assigned to the CPT + TD group, and 24 patients were recruited to the TD group. The ORR in the CPT + TD group was 38.3 vs. 25.0% in the TD group. The median PFS time was 6.7 months for the CPT + TD group and 3.1 months for the TD group. The median DORs for the CPT + TD and TD groups were 7.1 and 3.2 months, respectively. Most of the adverse effects (AEs) were grade 1 or 2. Serious AEs were reported in 19.7% of the patients. No treatment-related deaths were reported. CPT plus TD could serve as a new therapeutic strategy for patie...Continue Reading

References

Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A DimopoulosN Anagnostopoulos
Jun 5, 2003·British Journal of Haematology·Athanasios AnagnostopoulosRaymond Alexanian
Jul 21, 2006·Leukemia·B G M DurieUNKNOWN International Myeloma Working Group
Jan 12, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Kenneth C AndersonRashmi Kumar
Oct 28, 2015·Experimental Hematology·Hebing ZhouWenming Chen
Feb 17, 2017·Journal of Internal Medicine·O Landgren, K Iskander

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Citations

Apr 3, 2019·Cancers·Anna-Laura KretzJohannes Lemke
Mar 16, 2018·Cancer Metastasis Reviews·Xun YuanGen Sheng Wu
Oct 25, 2017·Antibodies·Agathe Dubuisson, Olivier Micheau
Jan 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyeonwoo JeEun Jung Lee
Apr 4, 2021·Cancers·Olivia A Diaz Arguello, Hidde J Haisma

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