Circulating 27-Hydroxycholesterol and Breast Cancer Risk: Results From the EPIC-Heidelberg Cohort

Journal of the National Cancer Institute
Da-Lin LuRenée T Fortner

Abstract

27-hydroxycholesterol (27HC) was the first identified endogenous selective estrogen receptor modulator (SERM); 27HC promoted growth and metastasis in experimental models of estrogen receptor-positive mammary cancer. There are no data on prediagnosis circulating 27HC and breast cancer risk in women. We conducted a nested case-control study in the well-characterized Heidelberg, Germany, cohort of the European Investigation into Cancer and Nutrition (EPIC) including 530 incident invasive breast cancer cases, each matched to up to two control participants (n = 1036). Serum 27HC was analyzed by liquid chromatography-mass spectrometry (LC-MS) in blood samples collected at study recruitment. Multivariable conditional logistic regression models were used to quantify the association between circulating 27HC and breast cancer risk overall, by tumor hormone receptor status (ie estrogen and progesterone receptors), and by menopausal status at blood collection. All statistical tests were two-sided. 27HC was not associated with breast cancer risk overall (relative risk [RR]Quartile4vsQuartile1 [Q4vsQ1] = 0.90, 95% confidence interval [CI] = 0.66 to 1.22). The association between 27HC and breast cancer risk differed by menopausal status at bl...Continue Reading

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Citations

Mar 3, 2019·Breast Cancer Research : BCR·Laura Garcia-Estevez, Gema Moreno-Bueno
Sep 25, 2020·Biomarkers in Medicine·Maria Ibac SawadaMarisa Passarelli
Feb 23, 2020·International Journal of Molecular Sciences·Hassan Nazih, Jean Marie Bard
Jul 23, 2020·British Journal of Pharmacology·Philippe de MedinaMarc Poirot
Jul 12, 2020·International Journal of Molecular Sciences·Arvand Asghari, Michihisa Umetani
Jun 19, 2019·Journal of Clinical Medicine·Lídia CedóJoan Carles Escolà-Gil
Aug 23, 2020·International Journal of Molecular Sciences·Augusto BleveFrancesca Maria Consonni
Sep 29, 2020·British Journal of Pharmacology·Alzbeta Kloudova-SpalenkovaPavel Soucek
Jan 14, 2021·International Journal of Molecular Sciences·Hsing-Ju Wu, Pei-Yi Chu
Oct 7, 2019·Molecular Cell·Romain RiscalM Celeste Simon
Jan 29, 2021·The FEBS Journal·Yuqin WangWilliam J Griffiths
Feb 20, 2021·Frontiers in Oncology·Tiffany ScullyEmily Jane Gallagher
Jan 8, 2021·Cancer Prevention Research·Michael N PassarelliJohn A Baron
May 24, 2021·Biochemical Pharmacology·Fiorella BiasiGiuseppe Poli

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