Circulating adhesion molecules and arterial stiffness

Cardiovascular Journal of Africa
I D KilicH Evrengul

Abstract

VCAM-1 and ICAM-1 are two important members of the immunoglobulin gene superfamily of adhesion molecules, and their potential role as biomarkers of diagnosis, severity and prognosis of cardiovascular disease has been investigated in a number of clinical studies. The aim of the present study was to determine the relationship between circulating ICAM-1 and VCAM-1 levels and aortic stiffness in patients referred for echocardiographic examination. Aortic distensibility was determined by echocardiography using systolic and diastolic aortic diameters in 63 consecutive patients referred for echocardiography. Venous samples were collected in the morning after a 12-hour overnight fast, and serum concentrations of ICAM-1 and VCAM-1 were measured using commercial enzyme immunoassay kits. Data of a total of 63 participants (mean age 55.6 ± 10.5 years, 31 male) were included in the study. Circulating levels of adhesion molecules were VCAM-1: 12.604 ± 3.904 ng/ml and ICAM-1: 45.417 ± 31.429 ng/ml. We were unable to demonstrate any correlation between indices of aortic stiffness and VCAM-1 and ICAM-1 levels. The role of soluble adhesion molecules in cardiovascular disease has not been fully established and clinical studies show inconsistent r...Continue Reading

Citations

Sep 1, 2015·Clinical & Experimental Ophthalmology·RuiPing GuGeZhi Xu
Mar 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Weizhong HanMin Li
Aug 3, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Anouk L M EikendalTim Leiner
Sep 16, 2017·Frontiers in Immunology·Ioana MozosAtanas G Atanasov

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