PMID: 640247Apr 1, 1978Paper

Circulating alanine disposal in diabetes mellitus

Diabetes
R H ChochinovJ A Moorhouse

Abstract

Alanine was selected for study as a representative circulating glucose precursor in relation to the question of the source of the excess circulating glucose in diabetes mellitus. U-14C alanine and U-14C glucose infusions were given to healthy subjects and to subjects with untreated mild maturity, severe maturity, and juvenile diabetes. Comparative studies after a 24-hour fast were made in healthy and in mildly diabetic subjects. The alanine production rate was unaltered by fasting or diabetes. The glucose production rate was unaltered by fasting but increased in diabetes in relation to the severity of the disease. The fractions of alanine-to-glucose and of glucose-from-alanine were increased by fasting. The effect of diabetes was different. The fraction of alanine-to-glucose was much less in mild maturity diabetes than in health, and it was increased only in juvenile diabetes. In all the diabetic groups the glucose-from-alanine fraction was much less than in health. In every group the change in the alanine oxidation rate was reciprocal to that in the alanine-derived glucogenesis rate. The results are consistent with the possibility that the principal source of the excess circulating glucose in diabetes is glycogen.

Citations

Dec 1, 1989·Diabetes/metabolism Reviews·E Ferrannini, L C Groop
Feb 23, 1999·Kidney International·M StumvollJ Gerich
Jun 1, 1991·Metabolism: Clinical and Experimental·S C KalhanS M Savin
Sep 1, 1993·The American Journal of Physiology·T S GuytonF C Battaglia
Aug 21, 2020·The Journal of Biological Chemistry·Ankit M Shah, Fredric E Wondisford
Sep 1, 1995·The American Journal of Physiology·G PerrielloJ E Gerich
Nov 1, 1984·The American Journal of Physiology·R D YangV R Young

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