PMID: 640234Mar 1, 1978Paper

Circulating alanine production and disposal in healthy subjects

Diabetes
R H ChochinovJ A Moorhouse

Abstract

Circulating-alanine production and disposal rates were estimated in eight healthy postabsorptive subjects by means of U-14C alanine and U-14C glucose infusions. The mean circulating-alanine production rate was 368 +/- S.E.M. 28 mumol/min. -1.8(2). Approximately 50 percent of circulating-alanine carbon exchanged rapidly with that of circulating lactate. Approximately 30 per cent of circulating alanine exchanged with protein stores. Other disposal was 29 +/- 2 per cent to circulating glucose and 40 +/- 4 per cent to oxidation. (1) The carbon moieties of circulating alanine and lactate are freely exchangeable. (2) Assessment of the contribution of alanine to gluconeogenesis will depend on establishing the extent to which the precursor pyruvate carbon is derived from glycolysis or from proteolysis. (3) If the principal pyruvate precursor is glycolysis, then the principal specific function of the glucose-alanine cycle appears to be ammonia transport.

Citations

Feb 1, 1988·Metabolism: Clinical and Experimental·S C KalhanS M Savin
Feb 1, 1980·The Proceedings of the Nutrition Society·D B Lindsay
Sep 1, 1981·The Proceedings of the Nutrition Society·V R Young
Jun 1, 1989·Diabetes/metabolism Reviews·S E BuchalterR Kreisberg
Apr 4, 2007·Cell Metabolism·Susan GrayMukesh K Jain
Jan 1, 1985·Annales Françaises D'anesthèsie Et De Rèanimation·S PoliC Perret
Jul 11, 1980·The American Journal of Physiology·G HetenyiM Berman
Aug 21, 2020·The Journal of Biological Chemistry·Ankit M Shah, Fredric E Wondisford
Jan 1, 1986·The American Journal of Physiology·R D YangV R Young
Aug 1, 1981·The American Journal of Physiology·S GoldenJ Katz
Nov 1, 1984·The American Journal of Physiology·R D YangV R Young
Jul 11, 1980·The American Journal of Physiology·D M FosterM Berman
Apr 1, 1988·The American Journal of Physiology·R R WolfeH Miyoshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Archives Internationales De Physiologie, De Biochimie Et De Biophysique
A Therminarias
Annals of Nutrition & Metabolism
H ConnorJ D Murray
© 2021 Meta ULC. All rights reserved