PMID: 8444501Jan 1, 1993Paper

Circulating alpha-actin protein in acute myocardial infarction

International Journal of Cardiology
A E AránegaA Aránega

Abstract

We used Western-blot analysis to investigate the possible presence in the bloodstream of the contractile protein alpha-actin in 70 patients diagnosed with acute myocardial infarction on the basis of clinical, electrocardiographic and laboratory (creatine kinase and lactate dehydrogenase) criteria. Circulating protein was identified with a monoclonal antibody specific for cardiac alpha-actin. Of the 70 control samples of blood, the immunoblot results were negative for alpha-actin in 98% of the cases. Of the 30 patients with skeletal muscle damage caused by surgery, 26 were negative for circulating alpha-actin. Of the 70 patients with acute myocardial infarction, circulating alpha-actin was found in 67 (95%) as a 43 kDa band in immunoblots; the highest circulating concentrations (0.0580 micrograms/microliters) were found in those with anterior acute myocardial infarction. Circulating alpha-actin was detected in samples taken between 1 and 180 h after the onset of pain, and showed a biphasic pattern of appearance. Our findings for serum alpha-actin, together with the relationship between serum concentrations of this protein and sex (p = 0.001), tobacco use (p = 0.007) and postepisode complications (p = 0.002), should make it possi...Continue Reading

References

Apr 1, 1978·The American Journal of Cardiology·C A TrahernD A Bigham
Dec 9, 1976·The New England Journal of Medicine·J S ForresterH J Swan
Oct 1, 1991·International Journal of Cardiology·A AránegaL Alvarez
Feb 1, 1986·Journal of the American College of Cardiology·J S PiroloG W Moore
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J C Chambers, J D Keene
Aug 22, 1985·The New England Journal of Medicine·J E Fielding
Jun 20, 1969·Science·H E Huxley
Nov 1, 1984·The American Journal of Cardiology·H A KatusB A Khaw
Mar 1, 1981·Clinical Science·P CumminsW A Littler

❮ Previous
Next ❯

Citations

Sep 1, 1995·International Journal of Cardiology·J PradosA Aranega
Jun 1, 1997·Clinical Biochemistry·A H Wu
Oct 26, 2005·British Journal of Sports Medicine·A Martínez-AmatA Aránega
Oct 4, 2011·Revista española de cardiología·Manuel F Jiménez-NavarroUNKNOWN Investigadores RECAVA (Red Temática de Investigación Cooperativa de Enfermedades Cardiovasculares)
Mar 23, 2017·Biochemistry. Biokhimii︠a︡·N P SudakovYu M Konstantinov
Oct 25, 2008·Human Reproduction·Paolo VercelliniPier Giorgio Crosignani
Jun 27, 2021·Cardiovascular Research·Andreas MangoldIrene M Lang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.