Circulating and Adipose Tissue mRNA Levels of Zinc-α2-Glycoprotein, Leptin, High-Molecular-Weight Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer Patients With or Without Obesity

Frontiers in Endocrinology
Huijuan ZhuFengying Gong

Abstract

To explore zinc-α2-glycoprotein (ZAG), leptin, high-molecular-weight adiponectin (HMW-ADPN), and tumor necrosis factor-alpha (TNF-α) levels in serum and subcutaneous and visceral white adipose tissue (sWAT and vWAT) among normal weight (NW) and overweight/obese (OW/OB) patients with colorectal cancer (CRC). A total of 76 Chinese CRC patients (42 NW + CRC, 34 OW/OB + CRC) and 40 healthy controls were recruited. Serum levels of the adipokines of interest were measured by an enzyme-linked immunosorbent assay method, and their mRNA levels in sWAT and vWAT were determined by reverse transcription quantitative PCR methods. Serum ZAG levels in the NW + CRC group were significantly increased by 11.7% compared with the healthy controls. Serum leptin levels in the OW/OB + CRC group were found to be increased by 57.7%, while HMW-ADPN levels were decreased by 23.5% when compared with the NW + CRC group of CRC patients. Additionally, ZAG mRNA levels in sWAT were significantly reduced by 78.8% in OB + CRC in comparison with NW + CRC patients. ZAG mRNA levels were negatively associated with body mass index (BMI) in sWAT but positively correlated with BMI in vWAT. TNF-α mRNA levels in vWAT of OB + CRC patients were significantly increased by 2...Continue Reading

References

Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I Díez-ItzaC López-Otín
Apr 16, 1996·Biochemical and Biophysical Research Communications·K MaedaK Matsubara
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F E DaviesG J Morgan
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 8, 2002·British Medical Bulletin·Peter Boyle, Maria Elena Leon
Jul 29, 2003·Diabetes Care·Manju ChandranRobert R Henry
Sep 24, 2004·Nature·Fran Balkwill, Lisa M Coussens
Jan 26, 2006·Journal of Leukocyte Biology·Markus NeumeierChrista Buechler
Oct 5, 2006·Journal of the National Cancer Institute·Susan M HenshallRobert L Sutherland
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alireza Ansary MoghaddamRachel Huxley
Jan 4, 2008·Cancer Research·Sangmi KimRobert S Sandler
Nov 4, 2008·International Journal of Colorectal Disease·Anna KumorEwa Małecka-Panas
Jun 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Y NingE L Giovannucci
Jul 22, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F-Y GongY-F Shi
Jul 23, 2009·The Journal of Clinical Endocrinology and Metabolism·David M SelvaRafael Simó
Sep 17, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rob C M van KruijsdijkFrank L J Visseren
Dec 17, 2009·Cancer Control : Journal of the Moffitt Cancer Center·Erin M SiegelDavid Shibata
Jun 3, 2010·Cancer Research·Taiki YamajiShoichiro Tsugane
Nov 30, 2010·Biochimica Et Biophysica Acta·Pedro L Prieto-HontoriaMaría J Moreno-Aliaga
Jun 8, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Catherine R GuffeyE Angela Murphy
May 16, 2014·Frontiers in Endocrinology·Ana I Pérez-HernándezGema Frühbeck
Jul 1, 2014·World Journal of Gastroenterology : WJG·Rakhi Kumari JoshiSang-Ah Lee
Jan 7, 2015·International Journal of Molecular Sciences·Yingming XueZhihai Peng
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Oct 24, 2015·International Journal of Colorectal Disease·S AmorM Granado
Sep 6, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cynthia DelgadoKirsten L Johansen
Jan 13, 2018·Nature Reviews. Neuroscience·Warren W Pan, Martin G Myers

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Citations

Apr 1, 2019·Biological Trace Element Research·Juliana Soares SeveroDilina do Nascimento Marreiro
Sep 27, 2020·BMC Medical Genetics·Ricardo M Cerda-FloresMaría Lourdes Garza-Rodríguez

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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