Circulating and local visfatin/Nampt/PBEF levels in spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats.

The Journal of Physiological Sciences : JPS
Pei WangChao-Yu Miao

Abstract

Visfatin (also known as nicotinamide phosphoribosyltransferase and pre-B cell colony-enhancing factor) is a multifunctional protein. Visfatin has been reported to be involved in several biological processes in the cardiovascular system, . However, the role of visfatin in hypertension is still unclear. In this study, we examined the circulating and local adipose visfatin levels in spontaneously hypertensive rats (SHR), stroke-prone spontaneously hypertensive rats (SHR-SP), and in their normotensive control Wistar-Kyoto (WKY). SHR and SHR-SP rats exhibited lower body weight, lower fat tissue and hypolipidemia. No differences of serum visfatin levels were observed in SHR/SHR-SP and WKY. Serum visfatin levels did not correlate to serum glucose, lipids, insulin, and fat pad weights, but significantly correlated to weights of skeletal muscle. Visfatin expression in visceral fat tissue was slightly lower in SHR-SP compared with that in WKY. Moreover, there were no significant differences of visfatin expression in skeletal muscles among WKY, SHR and SHR-SP. Finally, visfatin protein was detected in L6 rat skeletal muscle cell culture medium, indicating that visfatin was secreted from skeletal muscle cells. Thus, our results may provide...Continue Reading

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Citations

Sep 14, 2011·Clinical and Experimental Pharmacology & Physiology·Zhi-Yong LiChao-Yu Miao
Nov 6, 2015·Trends in Pharmacological Sciences·Pei Wang, Chao-Yu Miao
Feb 6, 2014·Acta Physiologica·T RomachoJ Eckel
Dec 13, 2017·Current Opinion in Psychiatry·Nady BraidyPerminder S Sachdev
Jan 27, 2011·Journal of Cardiovascular Pharmacology·Pei WangChao-Yu Miao
Sep 3, 2013·Physiology·Carmen Fiuza-LucesAlejandro Lucia

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