Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status).

PloS One
Jean Kyung PaikJong Ho Lee

Abstract

This study aimed to determine the association of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity in circulation and peripheral blood mononuclear cells (PBMCs) with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA(2) activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress. Eighty postmenopausal women (53.0±4.05 yr) and 96 premenopausal women (39.7±9.25 yr) participated in this study. Lp-PLA(2) activities, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β in plasma as well as in PBMCs were measured. Plasma ox-LDL was also measured. Postmenopausal women demonstrated higher circulating levels of ox-LDL and IL-6, as well as IL-6, TNF-α, and IL-1β in PBMCs, than premenopausal women. In both groups, plasma Lp-PLA(2) activity positively correlated with Lp-PLA(2) activity in PBMCs and plasma ox-LDL. In premenopausal women, Lp-PLA(2) activities in plasma and PBMCs positively correlated with IL-6, TNF-α, and IL-1β in PBMCs. In postmenopausal women, plasma ox-LDL positively correlated with PBMC cytokine production. In subgroup analysis of postmenopausal women according to plasma ox-LDL level (median level: 48.715 U/L), a ...Continue Reading

References

Jul 30, 1999·Biochemical and Biophysical Research Communications·K AsanoK Yamaguchi
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Caivano, P Cohen
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·D A Papanicolaou, A N Vgontzas
Apr 25, 2000·Annual Review of Medicine·W B Ershler, E T Keller
Nov 18, 2000·Biochimica Et Biophysica Acta·D A Six, E A Dennis
Jan 28, 2003·Progress in Lipid Research·Ken KarasawaMorio Setaka
Jul 17, 2003·Current Opinion in Lipidology·Muriel J Caslake, Chris J Packard
Oct 23, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos IribarrenCatherine M Loria
Feb 18, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Ewa Ninio
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew Zalewski, Colin Macphee
Oct 22, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Eric H YangAmir Lerman
Jun 30, 2006·Biochimica Et Biophysica Acta·Sonia-Athina Karabina, Ewa Ninio
Aug 12, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Yariv GerberVéronique L Roger
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Oct 3, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Dieuwke De KeyzerEwa Ninio
Jan 19, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jean Kyung PaikJong Ho Lee
Oct 1, 2011·Lipids in Health and Disease·Isis T SilvaNágila R T Damasceno

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Citations

Nov 19, 2019·JAMA : the Journal of the American Medical Association·Michael C HonigbergPradeep Natarajan
Nov 7, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Carlo Cervellati, Carlo M Bergamini
Mar 5, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mingyan YaoYiming Mu

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Methods Mentioned

BETA
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Software Mentioned

SPSS

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