Circulating and Synovial Fluid Heat Shock Protein 70 Are Correlated with Severity in Knee Osteoarthritis.

Cartilage
Srihatach NgarmukosSittisak Honsawek

Abstract

Heat shock proteins are molecules rapidly produced under conditions of environmental stress, and involve in protecting the cells structural integrity and function. Osteoarthritis (OA) is a chronic destructive disorder of the joints manifested by the ongoing deterioration and loss of articular cartilage. The present study aimed to analyze circulating and synovial heat shock protein (Hsp70) values in knee osteoarthritis patients and healthy controls and to determine their relationship with the radiographic grading of the severity of knee OA. Seventy-two subjects with knee OA and 30 control participants were recruited. Circulating and joint fluid Hsp70 values were quantified by commercially available enzyme-linked immunosorbent assay. Circulating Hsp70 was markedly higher in knee OA patients compared with that of healthy volunteers (P = 0.01). Correspondingly, synovial fluid Hsp70 was 3-fold greater than paired circulating Hsp70 samples (P < 0.001). Further analysis revealed that circulating and joint fluid Hsp70 values were significantly related with the radiographic severity of knee OA (r = 0.413, P < 0.001 and r = 0.658, P < 0.001, respectively). Subsequently, circulating Hsp70 value was directly associated with joint fluid Hsp...Continue Reading

References

Oct 1, 1985·Arthritis and Rheumatism·T KuboB V Treadwell
Jan 1, 1997·Scandinavian Journal of Rheumatology·K TakahashiY Hirasawa
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Jan 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laurent GrossinPierre Gillet
Sep 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hitoshi TonomuraToshikazu Kubo
Sep 15, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Naveen DakappagariHong Zhang
Nov 13, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Kenji A TakahashiToshikazu Kubo
Jul 14, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Ling ZhaoHai-Meng Zhang
Aug 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shinya FujitaToshikazu Kubo
Jan 22, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nobuyuki HiraokaToshikazu Kubo
Jul 13, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Irina V GuzhovaBoris A Margulis
Feb 24, 2016·Cancer Letters·Sanjay KumarManoj Mishra

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay
environmental stresses

Software Mentioned

Statistical Package for Social Sciences

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