Circulating and tumor-infiltrating gamma delta T Cells in patients with B-cell lymphomas

Leukemia & Lymphoma
Y KuriyamaK Ohyashiki

Abstract

In order to analyze the involvement of gamma delta T cells in the immune surveillance against B cell lymphomas (BCL), we investigated the proportion of circulating gamma delta T cells in 52 BCL patients using two-color flow cytometry, together with tumor-infiltrating gamma delta T cells in 22 of those patients. We found that the proportion of tumor-infiltrating gamma delta T cells in BCL patients was not different from that of lymph node gamma delta T cells in reactive hyperplasia patients. However, a decreased percentage of circulating gamma delta T cells were observed in indolent lymphoma (IL) and limited aggressive lymphoma (AL) patients when compared with normal controls. In contrast, as a result of a histogram, advanced AL patients were divided into two subgroups: the patients with increased circulating gamma delta T cells and those without any increase. However, there was no difference in the clinical features of between the two AL subgroups.

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Citations

Sep 3, 2008·Veterinary Clinical Pathology·Valentina Foglia ManzilloGaetano Oliva
Jul 16, 2005·Leukemia & Lymphoma·Volker Kunzmann, Martin Wilhelm
Nov 9, 2001·Leukemia & Lymphoma·K OhyashikiJ H Ohyashiki
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Dieter KabelitzMargot Zöller

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