Circulating and tumor-infiltrating myeloid-derived suppressor cells in cervical carcinoma patients

Oncology Letters
Liangliang WuTianyi Liu

Abstract

Myeloid-derived suppressor cells (MDSCs) serve an immunosuppressive role in human tumors. Human Lin-/low human leukocyte antigen-antigen D related (HLA-DR-) cluster of differentiation (CD)-11b+CD33+ MDSCs are closely linked with tumor staging, progression, clinical therapeutic efficacy and prognosis for various types of tumors. The present study employed multiparametric flow cytometry to measure the proportion of Lin-/lowHLA-DR-CD11b+CD33+ MDSCs in the peripheral blood of 105 cervical cancer patients and 50 healthy subjects. The level of MDSC was higher in tumor patients than in the normal control group and this was closely associated with clinical staging. Further analysis of tumor-infiltrating MDSCs was performed in 22 patients. The MDSC proportions in tumor tissue were significantly higher than those in the corresponding adjacent tissue. The phenotypic characteristics of Lin-/lowHLA-DR-CD11b+CD33+ MDSCs were then evaluated and the results revealed that they express high CD13 and CD39, and low CD115, CD117, CD124 and programmed cell death ligand 1; they were also devoid of CD14, CD15 and CD66b. MDSCs and T-cells from peripheral blood were sorted by flow cytometry for co-culture experiments. Lin-/lowHLA-DR-CD11b+CD33+ MDSCs fr...Continue Reading

Citations

Nov 7, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K V ArgyropoulosM Siakantaris
Jun 11, 2020·Cancer Immunology, Immunotherapy : CII·Naoki UmemuraHiroshi Sakagami
Aug 21, 2019·Frontiers in Oncology·Chenhao ZhouIan Hector Frazer
Sep 5, 2020·OncoTargets and Therapy·Luopei Guo, Keqin Hua
Aug 10, 2021·Oncoimmunology·Jamile Ramos da SilvaLuís Carlos de Souza Ferreira

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