Circulating and urinary microRNAs in kidney disease

Clinical Journal of the American Society of Nephrology : CJASN
Johan M Lorenzen, Thomas Thum

Abstract

microRNAs are small, noncoding RNAs that control gene/protein expression through target messengerRNA degradation and/or inhibition of protein synthesis. An array of experimental studies has shown the importance of microRNAs for disease initiation/progression. microRNAs are generally considered to act as intracellular modulators of gene expression. However, first studies in the cancer and cardiovascular field have elucidated that microRNAs are remarkably stable in the extracellular compartment (e.g., in blood or urine). The detection and quantification of circulating microRNAs may, thus, represent a novel noninvasive tool to detect and monitor disease activity. In addition, there might be a potential biologic relevance of circulating microRNAs for cell/cell communication. The aim of the present article is to give an outline of recent work on circulating and urinary microRNAs as well as their potential paracrine activity in kidney disease.

References

Apr 1, 1977·Journal of the National Cancer Institute·T P KarpetskyC C Levy
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Sep 17, 2004·Nature·Victor Ambros
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Apr 18, 2008·The Journal of Biological Chemistry·Pasquale FasanaroFabio Martelli
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Sep 6, 2008·PloS One·Shlomit GiladAyelet Chajut
Nov 13, 2008·PloS One·Melissa Piper HunterClay B Marsh
Mar 7, 2009·PloS One·Alex YuanDebora B Farber
Mar 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dany AnglicheauManikkam Suthanthiran
Dec 10, 2009·Science Signaling·Alma ZerneckeChristian Weber
Feb 27, 2010·Circulation Research·Anke J TijsenYigal M Pinto
Apr 1, 2010·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
Jun 11, 2010·European Heart Journal·Yuri D'AlessandraMaurizio C Capogrossi
Jul 3, 2010·Circulation Research·Stephan FichtlschererStefanie Dimmeler
Jul 10, 2010·Nucleic Acids Research·Kai WangDavid J Galas
Oct 21, 2010·Circulation. Cardiovascular Genetics·Shashi K GuptaThomas Thum
Oct 23, 2010·BMC Medicine·Calida S NealJonathan M Gleadle
Oct 30, 2010·Circulation Research·Sebastian F Mause, Christian Weber
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
Mar 23, 2011·Nature Reviews. Nephrology·Johan M LorenzenThomas Thum
Jun 7, 2011·Circulation. Cardiovascular Genetics·Yasuhide KuwabaraTakeshi Kimura
Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Johan M LorenzenThomas Thum
Jul 23, 2011·Circulation Research·Johann Bauersachs, Thomas Thum
Jul 27, 2011·Circulation·Jan FiedlerThomas Thum
Jul 29, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M J ScianV Mas
Aug 3, 2011·Journal of Molecular and Cellular Cardiology·Christian WideraThomas Thum
Aug 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M LorenzenT Thum
Sep 6, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Calida S NealJonathan M Gleadle
Dec 14, 2011·EMBO Molecular Medicine·Thomas Thum
Feb 14, 2012·Nature Cell Biology·Eduard HergenreiderStefanie Dimmeler

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Citations

Sep 11, 2012·The AAPS Journal·Rosalinde Masereeuw, Frans G M Russel
Jun 21, 2012·PloS One·Filippo MartinoThomas Thum
Mar 19, 2014·Biological Procedures Online·Thomas C RobertsMatthew J A Wood
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ana L TeixeiraRui Medeiros
Feb 19, 2015·The Journal of Physiology·Johan M Lorenzen
Nov 17, 2015·International Journal of Cardiology·Noemi BrunoAdriaan A Voors
Jan 27, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vineet Gupta, Jochen Reiser
Mar 19, 2015·Molecular Reproduction and Development·Vidya K Nagalakshmi, Jing Yu
Jul 13, 2013·Free Radical Biology & Medicine·Johan M LorenzenThomas Thum
Aug 30, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julia WilflingsederRainer Oberbauer
Jan 31, 2015·Journal of Cancer Research and Clinical Oncology·Yu-Zheng GeRui-Peng Jia
Feb 4, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Bénazir SiddeekMohamed Benahmed
Jul 22, 2014·Bioanalysis·Babak Basiri, Michael G Bartlett
Nov 12, 2014·Nature Reviews. Nephrology·Piera TrionfiniGiuseppe Remuzzi
May 31, 2016·Journal of Hepatology·Claire FrancozFrançois Durand
Oct 16, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M van de VrieL B Hilbrands
Mar 2, 2016·PloS One·Denis DelićRichard Urquhart
Jun 27, 2013·International Journal of Molecular Sciences·Jianghui Hou, Dan Zhao
Sep 28, 2017·Antioxidants & Redox Signaling·Baoqi FanRonald Ching Wan Ma
Aug 7, 2017·Journal of Nephrology·Grazia Maria VirzìClaudio Ronco
Nov 22, 2017·Blood Purification·Grazia Maria VirzìClaudio Ronco
Dec 20, 2017·Scientific Reports·Congcong ChenHuachun Weng
Apr 28, 2018·Human Molecular Genetics·Murali VijayanP Hemachandra Reddy
Oct 16, 2018·Journal of Cellular Biochemistry·Ziba Nariman-Saleh-FamSepideh Zununi Vahed
Feb 25, 2017·Journal of the American Society of Nephrology : JASN·Piera Trionfini, Ariela Benigni
Nov 8, 2013·Clinical and Experimental Nephrology·Tsuneo KontaIsao Kubota
Apr 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Juliana I SantosRui Medeiros
Feb 11, 2015·Expert Review of Molecular Diagnostics·Theofilos PapadopoulosJoost P Schanstra
Dec 10, 2019·American Journal of Physiology. Renal Physiology·Axel MuendleinHeinz Drexel
Feb 13, 2013·Clinical Chemistry·Johan M Lorenzen, Thomas Thum
Nov 2, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Huang Chun-MeiZhu Xiang-Yang
Mar 13, 2013·Expert Review of Molecular Diagnostics·Katrien Van RoosbroeckGeorge A Calin
Feb 27, 2015·Expert Review of Molecular Diagnostics·Jörg EllingerDimo Dietrich
Mar 29, 2014·Oncology Reports·Li-Li SunXiao-Yi Mi
Sep 1, 2018·Acta Diabetologica·Taís S AssmannDaisy Crispim
Apr 7, 2019·Molecular Neurobiology·Murali VijayanP Hemachandra Reddy
Jun 4, 2020·Journal of Experimental & Clinical Cancer Research : CR·Gonçalo Outeiro-PinhoCarmen Jerónimo
Sep 14, 2015·Non-coding RNA·Cristina BeltramiTimothy Bowen

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