Circulating androgens enhance sensitivity to testosterone self-administration in male hamsters

Pharmacology, Biochemistry, and Behavior
Anita N Dimeo, Ruth I Wood

Abstract

Young adult men are more likely to abuse steroids than individuals with low testosterone, including women, boys and older men. This suggests that circulating testosterone may enhance sensitivity to exogenous androgens. This hypothesis was tested using intracerebroventricular (i.c.v.) testosterone self-administration in orchidectomized males without testosterone (Orchx, n=8) and in orchidectomized males with chronic physiologic testosterone replacement (Orchx+T, n=8). Beginning 1 week after surgery, hamsters self-administered testosterone for 4 h/day in operant chambers at three doses (0.1, 1.0 and 2.0 microg/microl), each for 8 days. Afterwards, testosterone was replaced with vehicle for 8 days to test extinction. At 1.0 and 2.0 microg/microl, Orchx+T and Orchx males self-administered similar amounts of testosterone. However, at 0.1 microg/microl testosterone, only Orchx+T males showed a significant preference for the active nose-poke (Orchx+T active: 35.1+/-8.4 responses/4 h [mean+/-S.E.M.] vs. inactive: 16.5+/-1.7 responses/4 h, p<0.05; Orchx active: 16.7+/-4.9 responses/4 h vs. inactive: 13.5+/-3.1 responses/4 h, p>0.05). There was little change in operant behavior during extinction in Orchx+T males. However, when vehicle re...Continue Reading

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Citations

Feb 9, 2010·Psychoneuroendocrinology·Satoru M SatoRuth I Wood
Jan 4, 2006·Hormones and Behavior·Anita N Dimeo, Ruth I Wood
Jun 25, 2015·Regulatory Toxicology and Pharmacology : RTP·David V GauvinTheodore J Baird
Feb 6, 2007·Brain Research·Anita Nagypál, Ruth I Wood
Sep 18, 2015·Frontiers in Neuroscience·Emanuela MhillajLuigia Trabace
Sep 15, 2005·Psychoneuroendocrinology·Anita N Dimeo, Ruth I Wood
Feb 16, 2008·Frontiers in Neuroendocrinology·Ruth I Wood

Related Concepts

Androgen Effect
Operant Conditioning
Dose-Response Relationship, Drug
Extinction, Psychological
Cricetus
Injections, Intraventricular
Mesocricetus
Orchiectomy
Self Administration
Sexual Behavior, Animal

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