Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier

Hypertension
Vinicia Campana BiancardiJavier E Stern

Abstract

Angiotensin II-mediated vascular brain inflammation emerged as a novel pathophysiological mechanism in neurogenic hypertension. However, the precise underlying mechanisms and functional consequences in relation to blood-brain barrier (BBB) integrity and central angiotensin II actions mediating neurohumoral activation in hypertension are poorly understood. Here, we aimed to determine whether BBB permeability within critical hypothalamic and brain stem regions involved in neurohumoral regulation was altered during hypertension. Using digital imaging quantification after intravascularly injected fluorescent dyes and immunohistochemistry, we found increased BBB permeability, along with altered key BBB protein constituents, in spontaneously hypertensive rats within the hypothalamic paraventricular nucleus, the nucleus of the solitary tract, and the rostral ventrolateral medulla, all critical brain regions known to contribute to neurohumoral activation during hypertension. BBB disruption, including increased permeability and downregulation of constituent proteins, was prevented in spontaneously hypertensive rats treated with the AT1 receptor antagonist losartan, but not with hydralazine, a direct vasodilator. Importantly, we found ci...Continue Reading

References

Nov 1, 1990·Microvascular Research·S Z LinJ Fenstermacher
Feb 1, 1990·Neurosurgery·M K Gumerlock, E A Neuwelt
Jun 1, 1989·Hypertension·G L Baumbach, D D Heistad
Feb 1, 1989·Journal of Neuroimmunology·N H SternbergerC R Shear
Jul 22, 1993·Annals of the New York Academy of Sciences·A M Zardetto-SmithA K Johnson
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·A V Ferguson, J S Bains
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Guo-Qing ZhuWei Wang
Jan 18, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen L BarnesMichael C Andresen
Mar 27, 2003·Journal of Cardiovascular Pharmacology·Jun Ming WangFrans H H Leenen
May 29, 2003·British Journal of Pharmacology·Shereeni J Veerasingham, Mohan K Raizada
Oct 3, 2003·Trends in Neurosciences·Maiken NedergaardSteven A Goldman
Jan 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K J Latchford, A V Ferguson
Jul 20, 2004·Histochemistry and Cell Biology·Masaki UenoToshitaka Nakagawa
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Aug 10, 2006·Clinical and Experimental Pharmacology & Physiology·Valin RejaPaul M Pilowsky
May 24, 2007·Current Hypertension Reports·John W OsbornMohan K Raizada
Sep 22, 2007·Current Opinion in Lipidology·Frank HeldermanRob Krams
Apr 30, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julian F R PatonSergey Kasparov
Jul 8, 2008·Journal of Chemical Neuroanatomy·Ebba NorstedBjörn Meister
Jan 8, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Melissa A Fleegal-DeMottaWilliam A Banks
Mar 5, 2009·Cellular and Molecular Neurobiology·Julius BenickyJuan M Saavedra
May 14, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pauline M Smith, Alastair V Ferguson
Jun 16, 2010·Hypertension·Peng ShiMohan K Raizada
Nov 4, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Shantel A VitalD Neil Granger
Sep 1, 1996·Clinical and Experimental Pharmacology & Physiology·M J McKinleyB J Oldfield

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Citations

Aug 12, 2014·The Journal of Physiology·Jessica R Ivy, Matthew A Bailey
Nov 6, 2015·Experimental Physiology·Elizabeth B Oliveira-SalesJulian F R Paton
Dec 2, 2014·Autonomic Neuroscience : Basic & Clinical·Wesley G CorrêaHelio C Salgado
Sep 24, 2015·Neuropeptides·Patrícia M FerreiraMaria J Campagnole-Santos
Mar 19, 2016·Cellular and Molecular Neurobiology·T Michael De Silva, Frank M Faraci
Feb 3, 2015·Experimental Physiology·Ruy R CamposCassia T Bergamaschi
Aug 12, 2014·BioMed Research International·Sheng ChenJohn H Zhang
May 4, 2015·Journal of Neuroinflammation·Pawel J WinklewskiUrszula Demkow
Dec 3, 2014·Autonomic Neuroscience : Basic & Clinical·Karla K V Haack, Irving H Zucker
Aug 5, 2016·Current Opinion in Nephrology and Hypertension·Pawel J WinklewskiUrszula Demkow
Mar 6, 2018·The British Journal of Nutrition·Daniela P StocherCristiane Matté
Apr 14, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dawid WalasJulian Fr Paton
May 23, 2018·American Journal of Hypertension·Patricia Martinez-QuinonesCamilla F Wenceslau
Apr 11, 2015·Current Hypertension Reports·Casey Y Carmichael, Richard D Wainford
May 4, 2017·Hypertension·Katrina M Mirabito Colafella, A H Jan Danser
Apr 12, 2017·Hypertension·Bibi S van ThielA H Jan Danser
Apr 16, 2016·Circulation Research·Monica M SantistebanMohan K Raizada
Sep 2, 2015·Hypertension·Colin N Young, Robin L Davisson
May 13, 2015·Circulation Research·Monica M SantistebanJasenka Zubcevic
Oct 12, 2018·The Journal of Physiology·E N Bardsley, D J Paterson
Dec 26, 2018·Experimental Physiology·Erik N T P BakkerEd VanBavel
Feb 26, 2019·Journal of Neuroendocrinology·Cintia Yamila PorcariAndré Souza Mecawi
Feb 23, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Valdir A Braga
Jun 19, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Annette D de KloetColin Sumners
Dec 8, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Vinicia Campana BiancardiJavier E Stern
Feb 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerHanjun Wang
May 12, 2016·American Journal of Physiology. Endocrinology and Metabolism·Cheng HanDongsheng Cai
Aug 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Roger A DampneyHui-Lin Pan

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