Circulating Anti-Nuclear Antibodies in Systemic Sclerosis: Utility in Diagnosis and Disease Subsetting

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Masataka Kuwana

Abstract

The presence of circulating anti-nuclear antibodies (ANAs) is a hallmark of immune dysregulation in patients with systemic sclerosis (SSc). Currently, a variety of SSc-specific ANAs, including anticentromere, anti-topoisomerase I, and anti-RNA polymerase III antibodies, have been well characterized, and their commercial kits are available worldwide. Since these autoantibodies are specifically detected in SSc patients and are associated with unique sets of disease manifestations, they are widely used in routine clinical practice for diagnosis, clinical subgrouping, and prediction of future organ involvements and prognosis. In addition, SSc-specific ANAs are also useful in predicting future development of SSc in patients with Raynaud's phenomenon without any scleroderma skin changes, because their production often precedes onset of SSc symptoms. Application of circulating SSc-specific ANA measurement to clinical practice has greatly improved patient care, but utility of the autoantibody testing could be maximized by combining other clinical information, such as degree and extent of skin thickness and disease duration.

References

Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y MoroiE M Tan
Jan 13, 2001·Annals of the Rheumatic Diseases·R BrouwerW J van Venrooij
Jul 24, 2001·Arthritis and Rheumatism·O H GündüzT A Medsger
Dec 17, 2002·Arthritis and Rheumatism·Hans Van EenennaamGer J M Pruijn
Mar 3, 2007·The Journal of Clinical Investigation·John Varga, David Abraham
Jul 3, 2007·QJM : Monthly Journal of the Association of Physicians·H PennC P Denton
Apr 1, 2009·Arthritis and Rheumatism·Rohit AggarwalThomas A Medsger
Jul 1, 2009·Arthritis and Rheumatism·Noreen FertigCarol A Feghali-Bostwick
Mar 8, 2012·Arthritis Research & Therapy·Marie HudsonMarvin J Fritzler
May 21, 2013·Annals of the Rheumatic Diseases·J Gerry CoghlanUNKNOWN DETECT study group
Feb 15, 2014·Arthritis Research & Therapy·Pia MoinzadehVoon H Ong
Oct 3, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sankalp Virendrakumar Bhavsar, Raj Carmona
Jan 13, 2015·Seminars in Arthritis and Rheumatism·Gloria A SalazarMaureen D Mayes

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Citations

Nov 21, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·B MiziołekL Brzezińska-Wcisło
Nov 5, 2019·Arthritis & Rheumatology·Svetlana I NihtyanovaChristopher P Denton
Jul 14, 2017·Auto- Immunity Highlights·Silvia SirottiCarlo Selmi
Feb 23, 2019·International Journal of Molecular Sciences·Mara SimopoulouMichael Koutsilieris
Sep 21, 2019·Expert Review of Clinical Immunology·Dušanka Martinović Kaliterna, Marin Petrić
Jan 5, 2019·Clinical Reviews in Allergy & Immunology·Anna StochmalLidia Rudnicka
Jun 17, 2021·Inflammation and Regeneration·Yuko Ota, Masataka Kuwana
Aug 12, 2021·Therapeutic Advances in Musculoskeletal Disease·Masataka KuwanaAlbert Selva-O'Callaghan

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